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A Case of Transformation of Primary Cutaneous Follicle Center Lymphoma to Diffuse Large B-Cell Lymphoma Involving the Parotid Gland and Cervical Lymph Nodes

Patient: Male, 40 Final Diagnosis: Primary cutaneous follicular lymphoma Symptoms: Scalp mass Medication: — Clinical Procedure: Radiation Specialty: Oncology OBJECTIVE: Rare co-existance of disease or pathology BACKGROUND: Transformation of primary cutaneous follicle center lymphoma (PCFCL), a low-g...

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Autores principales: King, Maurice L., Thomas, Toms Vengaloor, Albert, Ashley A., Joseph, Sanjay, Nair, Lakshmi Ramachandran, Lam, John T., Woods, William C., Nittala, Mary, Vijayakumar, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735615/
https://www.ncbi.nlm.nih.gov/pubmed/31462626
http://dx.doi.org/10.12659/AJCR.917389
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author King, Maurice L.
Thomas, Toms Vengaloor
Albert, Ashley A.
Joseph, Sanjay
Nair, Lakshmi Ramachandran
Lam, John T.
Woods, William C.
Nittala, Mary
Vijayakumar, Srinivasan
author_facet King, Maurice L.
Thomas, Toms Vengaloor
Albert, Ashley A.
Joseph, Sanjay
Nair, Lakshmi Ramachandran
Lam, John T.
Woods, William C.
Nittala, Mary
Vijayakumar, Srinivasan
author_sort King, Maurice L.
collection PubMed
description Patient: Male, 40 Final Diagnosis: Primary cutaneous follicular lymphoma Symptoms: Scalp mass Medication: — Clinical Procedure: Radiation Specialty: Oncology OBJECTIVE: Rare co-existance of disease or pathology BACKGROUND: Transformation of primary cutaneous follicle center lymphoma (PCFCL), a low-grade B-cell non-Hodgkin lymphoma (NHL), into a high-grade NHL is rare with uncertain prognosis and treatment. A case is reported of a 40-year-old man who presented with a scalp mass that was diagnosed histologically as PCFCL. Imaging of the head and neck identified diffuse large B-cell lymphoma (DLBCL) involving the parotid gland and cervical lymph nodes, which responded well to radiation therapy. CASE REPORT: A 40-year-old African American man presented with a two-year history of a progressively enlarging scalp mass that measured 10.5×7.1×6.6 cm. Histology showed a low-grade lymphoma with a follicular pattern. Immunohistochemistry was positive for B-cell markers and Bcl-6, consistent with a diagnosis of PCFCL. Computed tomography (CT) identified a 4.9×3.7×3.4 cm mass in the left parotid gland with bilateral cervical lymphadenopathy that had been present for the previous two or three months. The diagnosis of DLBCL was made on histology from a needle biopsy. Treatment began with rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (R-EPOCH) chemotherapy, followed by radiation therapy to the scalp, both sides of the neck, and left parotid gland. At four-month follow-up, combined positron emission tomography (PET) and CT showed only diffuse low-level uptake in the scalp and parotid gland. CONCLUSIONS: Transformation of low-grade PCFCL to high-grade DLBCL is rare, and the approach to treatment varies. This case showed a good response to chemotherapy and radiation therapy.
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spelling pubmed-67356152019-09-20 A Case of Transformation of Primary Cutaneous Follicle Center Lymphoma to Diffuse Large B-Cell Lymphoma Involving the Parotid Gland and Cervical Lymph Nodes King, Maurice L. Thomas, Toms Vengaloor Albert, Ashley A. Joseph, Sanjay Nair, Lakshmi Ramachandran Lam, John T. Woods, William C. Nittala, Mary Vijayakumar, Srinivasan Am J Case Rep Articles Patient: Male, 40 Final Diagnosis: Primary cutaneous follicular lymphoma Symptoms: Scalp mass Medication: — Clinical Procedure: Radiation Specialty: Oncology OBJECTIVE: Rare co-existance of disease or pathology BACKGROUND: Transformation of primary cutaneous follicle center lymphoma (PCFCL), a low-grade B-cell non-Hodgkin lymphoma (NHL), into a high-grade NHL is rare with uncertain prognosis and treatment. A case is reported of a 40-year-old man who presented with a scalp mass that was diagnosed histologically as PCFCL. Imaging of the head and neck identified diffuse large B-cell lymphoma (DLBCL) involving the parotid gland and cervical lymph nodes, which responded well to radiation therapy. CASE REPORT: A 40-year-old African American man presented with a two-year history of a progressively enlarging scalp mass that measured 10.5×7.1×6.6 cm. Histology showed a low-grade lymphoma with a follicular pattern. Immunohistochemistry was positive for B-cell markers and Bcl-6, consistent with a diagnosis of PCFCL. Computed tomography (CT) identified a 4.9×3.7×3.4 cm mass in the left parotid gland with bilateral cervical lymphadenopathy that had been present for the previous two or three months. The diagnosis of DLBCL was made on histology from a needle biopsy. Treatment began with rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (R-EPOCH) chemotherapy, followed by radiation therapy to the scalp, both sides of the neck, and left parotid gland. At four-month follow-up, combined positron emission tomography (PET) and CT showed only diffuse low-level uptake in the scalp and parotid gland. CONCLUSIONS: Transformation of low-grade PCFCL to high-grade DLBCL is rare, and the approach to treatment varies. This case showed a good response to chemotherapy and radiation therapy. International Scientific Literature, Inc. 2019-08-29 /pmc/articles/PMC6735615/ /pubmed/31462626 http://dx.doi.org/10.12659/AJCR.917389 Text en © Am J Case Rep, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
King, Maurice L.
Thomas, Toms Vengaloor
Albert, Ashley A.
Joseph, Sanjay
Nair, Lakshmi Ramachandran
Lam, John T.
Woods, William C.
Nittala, Mary
Vijayakumar, Srinivasan
A Case of Transformation of Primary Cutaneous Follicle Center Lymphoma to Diffuse Large B-Cell Lymphoma Involving the Parotid Gland and Cervical Lymph Nodes
title A Case of Transformation of Primary Cutaneous Follicle Center Lymphoma to Diffuse Large B-Cell Lymphoma Involving the Parotid Gland and Cervical Lymph Nodes
title_full A Case of Transformation of Primary Cutaneous Follicle Center Lymphoma to Diffuse Large B-Cell Lymphoma Involving the Parotid Gland and Cervical Lymph Nodes
title_fullStr A Case of Transformation of Primary Cutaneous Follicle Center Lymphoma to Diffuse Large B-Cell Lymphoma Involving the Parotid Gland and Cervical Lymph Nodes
title_full_unstemmed A Case of Transformation of Primary Cutaneous Follicle Center Lymphoma to Diffuse Large B-Cell Lymphoma Involving the Parotid Gland and Cervical Lymph Nodes
title_short A Case of Transformation of Primary Cutaneous Follicle Center Lymphoma to Diffuse Large B-Cell Lymphoma Involving the Parotid Gland and Cervical Lymph Nodes
title_sort case of transformation of primary cutaneous follicle center lymphoma to diffuse large b-cell lymphoma involving the parotid gland and cervical lymph nodes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735615/
https://www.ncbi.nlm.nih.gov/pubmed/31462626
http://dx.doi.org/10.12659/AJCR.917389
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