Mitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senescent melanoma cells

Cellular senescence is an endpoint of chemotherapy, and targeted therapies in melanoma and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing treatment outcomes. Metabolic interventions can modulate the SASP, and an enhanced mitochondrial e...

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Detalles Bibliográficos
Autores principales: Martínez, Jennyfer, Tarallo, Doménica, Martínez-Palma, Laura, Victoria, Sabina, Bresque, Mariana, Rodríguez-Bottero, Sebastián, Marmisolle, Inés, Escande, Carlos, Cassina, Patricia, Casanova, Gabriela, Bollati-Fogolín, Mariela, Agorio, Caroline, Moreno, María, Quijano, Celia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735661/
https://www.ncbi.nlm.nih.gov/pubmed/31431479
http://dx.doi.org/10.1042/BCJ20190405

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