A3 Molecular epidemiology of HIV-1 in Nigeria

Nigeria has been reported to have the highest number of AIDS-related deaths in the world. In this study, we aimed to use molecular epidemiology to investigate the HIV-1 diversity and phylodynamics in Nigeria. We analyzed 1,442 HIV-1 pol sequences collected from 1999 to 2014 from seven geopolitical z...

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Autores principales: Nazziwa, J, Faria, N, Chaplin, B, Rawizza, H, Dakum, P, Abimiku, A, Charurat, M, Ndembi, N, Esbjörnsson, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstract Overview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735677/
http://dx.doi.org/10.1093/ve/vez002.002
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author Nazziwa, J
Faria, N
Chaplin, B
Rawizza, H
Dakum, P
Abimiku, A
Charurat, M
Ndembi, N
Esbjörnsson, J
author_facet Nazziwa, J
Faria, N
Chaplin, B
Rawizza, H
Dakum, P
Abimiku, A
Charurat, M
Ndembi, N
Esbjörnsson, J
author_sort Nazziwa, J
collection PubMed
description Nigeria has been reported to have the highest number of AIDS-related deaths in the world. In this study, we aimed to use molecular epidemiology to investigate the HIV-1 diversity and phylodynamics in Nigeria. We analyzed 1,442 HIV-1 pol sequences collected from 1999 to 2014 from seven geopolitical zones in Nigeria. The main circulating strains, CRF02_AG (44.1% of the analyzed sequences), Subtype G (8.3%), and CRF43_02G (16.4%), were introduced to Nigeria in the 1960s, 1970s, and 1980s, respectively. The number of effective infections decreased in Nigeria after the introduction of free antiretroviral treatment in 2006. We also found a significant number of unique recombinant forms (22.7%), the majority of which were recombinants between the two or three of the main circulating strains described above. In addition, phylogeographic analysis indicates multiple occasions of HIV-1 transmission between Lagos and Abuja (two of the main cities in Nigeria). Our results may be relevant for HIV-1 intervention and contribute in making informed decisions in strategies aiming at reducing further spread of HIV-1 in Nigeria.
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spelling pubmed-67356772019-09-16 A3 Molecular epidemiology of HIV-1 in Nigeria Nazziwa, J Faria, N Chaplin, B Rawizza, H Dakum, P Abimiku, A Charurat, M Ndembi, N Esbjörnsson, J Virus Evol Abstract Overview Nigeria has been reported to have the highest number of AIDS-related deaths in the world. In this study, we aimed to use molecular epidemiology to investigate the HIV-1 diversity and phylodynamics in Nigeria. We analyzed 1,442 HIV-1 pol sequences collected from 1999 to 2014 from seven geopolitical zones in Nigeria. The main circulating strains, CRF02_AG (44.1% of the analyzed sequences), Subtype G (8.3%), and CRF43_02G (16.4%), were introduced to Nigeria in the 1960s, 1970s, and 1980s, respectively. The number of effective infections decreased in Nigeria after the introduction of free antiretroviral treatment in 2006. We also found a significant number of unique recombinant forms (22.7%), the majority of which were recombinants between the two or three of the main circulating strains described above. In addition, phylogeographic analysis indicates multiple occasions of HIV-1 transmission between Lagos and Abuja (two of the main cities in Nigeria). Our results may be relevant for HIV-1 intervention and contribute in making informed decisions in strategies aiming at reducing further spread of HIV-1 in Nigeria. Oxford University Press 2019-08-22 /pmc/articles/PMC6735677/ http://dx.doi.org/10.1093/ve/vez002.002 Text en © Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access publication distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Abstract Overview
Nazziwa, J
Faria, N
Chaplin, B
Rawizza, H
Dakum, P
Abimiku, A
Charurat, M
Ndembi, N
Esbjörnsson, J
A3 Molecular epidemiology of HIV-1 in Nigeria
title A3 Molecular epidemiology of HIV-1 in Nigeria
title_full A3 Molecular epidemiology of HIV-1 in Nigeria
title_fullStr A3 Molecular epidemiology of HIV-1 in Nigeria
title_full_unstemmed A3 Molecular epidemiology of HIV-1 in Nigeria
title_short A3 Molecular epidemiology of HIV-1 in Nigeria
title_sort a3 molecular epidemiology of hiv-1 in nigeria
topic Abstract Overview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735677/
http://dx.doi.org/10.1093/ve/vez002.002
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