XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence

XAB2 is a multi-functional protein participating processes including transcription, splicing, DNA repair and mRNA export. Here, we report POLR2A, the largest catalytic subunit of RNA polymerase II, as a major target gene down-regulated after XAB2 depletion. XAB2 depletion led to severe splicing defe...

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Detalles Bibliográficos
Autores principales: Hou, Shuai, Qu, Dajun, Li, Yue, Zhu, Baohui, Liang, Dapeng, Wei, Xinyue, Tang, Wei, Zhang, Qian, Hao, Jiaojiao, Guo, Wei, Wang, Weijie, Zhao, Siqi, Wang, Qi, Azam, Sikandar, Khan, Misbah, Zhao, Haidong, Zhang, Liye, Lei, Haixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735682/
https://www.ncbi.nlm.nih.gov/pubmed/31216022
http://dx.doi.org/10.1093/nar/gkz532

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