Clinical Impact of Revised Cefepime Breakpoint in Patients With Enterobacteriaceae Bacteremia

The impact of the revised Clinical and Laboratory Standards Institute interpretative criteria for cefepime in Enterobacteriaceae remains unclear. We applied the new breakpoint on 644 previously defined cefepime-susceptible Enterobacteriaceae isolates. We found no differences in mortality or microbio...

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Autores principales: Foong, Kap Sum, Carlson, Abigail L, Munigala, Satish, Burnham, Carey-Ann D, Warren, David K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735685/
https://www.ncbi.nlm.nih.gov/pubmed/31660387
http://dx.doi.org/10.1093/ofid/ofz341
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author Foong, Kap Sum
Carlson, Abigail L
Munigala, Satish
Burnham, Carey-Ann D
Warren, David K
author_facet Foong, Kap Sum
Carlson, Abigail L
Munigala, Satish
Burnham, Carey-Ann D
Warren, David K
author_sort Foong, Kap Sum
collection PubMed
description The impact of the revised Clinical and Laboratory Standards Institute interpretative criteria for cefepime in Enterobacteriaceae remains unclear. We applied the new breakpoint on 644 previously defined cefepime-susceptible Enterobacteriaceae isolates. We found no differences in mortality or microbiological failure, regardless of isolates being susceptible or cefepime-susceptible dose-dependent by current criteria.
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spelling pubmed-67356852019-09-16 Clinical Impact of Revised Cefepime Breakpoint in Patients With Enterobacteriaceae Bacteremia Foong, Kap Sum Carlson, Abigail L Munigala, Satish Burnham, Carey-Ann D Warren, David K Open Forum Infect Dis Brief Report The impact of the revised Clinical and Laboratory Standards Institute interpretative criteria for cefepime in Enterobacteriaceae remains unclear. We applied the new breakpoint on 644 previously defined cefepime-susceptible Enterobacteriaceae isolates. We found no differences in mortality or microbiological failure, regardless of isolates being susceptible or cefepime-susceptible dose-dependent by current criteria. Oxford University Press 2019-07-28 /pmc/articles/PMC6735685/ /pubmed/31660387 http://dx.doi.org/10.1093/ofid/ofz341 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Foong, Kap Sum
Carlson, Abigail L
Munigala, Satish
Burnham, Carey-Ann D
Warren, David K
Clinical Impact of Revised Cefepime Breakpoint in Patients With Enterobacteriaceae Bacteremia
title Clinical Impact of Revised Cefepime Breakpoint in Patients With Enterobacteriaceae Bacteremia
title_full Clinical Impact of Revised Cefepime Breakpoint in Patients With Enterobacteriaceae Bacteremia
title_fullStr Clinical Impact of Revised Cefepime Breakpoint in Patients With Enterobacteriaceae Bacteremia
title_full_unstemmed Clinical Impact of Revised Cefepime Breakpoint in Patients With Enterobacteriaceae Bacteremia
title_short Clinical Impact of Revised Cefepime Breakpoint in Patients With Enterobacteriaceae Bacteremia
title_sort clinical impact of revised cefepime breakpoint in patients with enterobacteriaceae bacteremia
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735685/
https://www.ncbi.nlm.nih.gov/pubmed/31660387
http://dx.doi.org/10.1093/ofid/ofz341
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