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High efficiency error suppression for accurate detection of low-frequency variants

Detection of cancer-associated somatic mutations has broad applications for oncology and precision medicine. However, this becomes challenging when cancer-derived DNA is in low abundance, such as in impure tissue specimens or in circulating cell-free DNA. Next-generation sequencing (NGS) is particul...

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Detalles Bibliográficos
Autores principales:	Wang, Ting Ting, Abelson, Sagi, Zou, Jinfeng, Li, Tiantian, Zhao, Zhen, Dick, John E, Shlush, Liran I, Pugh, Trevor J, Bratman, Scott V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735726/ https://www.ncbi.nlm.nih.gov/pubmed/31127310 http://dx.doi.org/10.1093/nar/gkz474

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