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The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1

PURPOSE: Diabetes leads to the downregulation of the retinal Kir4.1 channels and Müller cell dysfunction. The insulin receptor substrate-1 (IRS-1) is a critical regulator of insulin signaling in Müller cells. Circadian rhythms play an integral role in normal physiology; however, diabetes leads to a...

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Detalles Bibliográficos
Autores principales:	Luo, Qianyi, Xiao, Yucheng, Alex, Alpha, Cummins, Theodore R., Bhatwadekar, Ashay D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2019
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735779/ https://www.ncbi.nlm.nih.gov/pubmed/31042800 http://dx.doi.org/10.1167/iovs.18-26045

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