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Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair

Non-homologous end-joining (NHEJ) plays an important role in double-strand break (DSB) repair of DNA. Recent studies have shown that the error patterns of NHEJ are strongly biased by sequence context, but these studies were based on relatively few templates. To investigate this more thoroughly, we s...

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Detalles Bibliográficos
Autores principales:	Chen, Wei, McKenna, Aaron, Schreiber, Jacob, Haeussler, Maximilian, Yin, Yi, Agarwal, Vikram, Noble, William Stafford, Shendure, Jay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735782/ https://www.ncbi.nlm.nih.gov/pubmed/31165867 http://dx.doi.org/10.1093/nar/gkz487

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