SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina

Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of self-propagation in the genome with potential mutagenic outcomes. How somatic cells restrict L1 activity and how this process becomes dysfunctional during aging and in cancer cells is poorly understood. L1s are...

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Detalles Bibliográficos
Autores principales: Vazquez, Berta N, Thackray, Joshua K, Simonet, Nicolas G, Chahar, Sanjay, Kane-Goldsmith, Noriko, Newkirk, Simon J, Lee, Suman, Xing, Jinchuan, Verzi, Michael P, An, Wenfeng, Vaquero, Alejandro, Tischfield, Jay A, Serrano, Lourdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735864/
https://www.ncbi.nlm.nih.gov/pubmed/31226208
http://dx.doi.org/10.1093/nar/gkz519

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