Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability

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Common fragile sites (CFSs) are conserved genomic regions prone to break under conditions of replication stress (RS). Thus, CFSs are hotspots for rearrangements in cancer and contribute to its chromosomal instability. Here, we have performed a global analysis of proteins that recruit to CFSs upon mi...

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Detalles Bibliográficos
Autores principales: Pladevall-Morera, David, Munk, Stephanie, Ingham, Andreas, Garribba, Lorenza, Albers, Eliene, Liu, Ying, Olsen, Jesper V, Lopez-Contreras, Andres J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735892/
https://www.ncbi.nlm.nih.gov/pubmed/31180492
http://dx.doi.org/10.1093/nar/gkz510

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