An expanded landscape of human long noncoding RNA

Long noncoding RNAs (lncRNAs) are emerging as key regulators of multiple essential biological processes involved in physiology and pathology. By analyzing the largest compendium of 14,166 samples from normal and tumor tissues, we significantly expand the landscape of human long noncoding RNA with a...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Shuai, Cheng, Si-Jin, Ren, Li-Chen, Wang, Qian, Kang, Yu-Jian, Ding, Yang, Hou, Mei, Yang, Xiao-Xu, Lin, Yuan, Liang, Nan, Gao, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Data Resources and Analyses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735957/
https://www.ncbi.nlm.nih.gov/pubmed/31350901
http://dx.doi.org/10.1093/nar/gkz621
_version_ 1783450442185834496
author Jiang, Shuai
Cheng, Si-Jin
Ren, Li-Chen
Wang, Qian
Kang, Yu-Jian
Ding, Yang
Hou, Mei
Yang, Xiao-Xu
Lin, Yuan
Liang, Nan
Gao, Ge
author_facet Jiang, Shuai
Cheng, Si-Jin
Ren, Li-Chen
Wang, Qian
Kang, Yu-Jian
Ding, Yang
Hou, Mei
Yang, Xiao-Xu
Lin, Yuan
Liang, Nan
Gao, Ge
author_sort Jiang, Shuai
collection PubMed
description Long noncoding RNAs (lncRNAs) are emerging as key regulators of multiple essential biological processes involved in physiology and pathology. By analyzing the largest compendium of 14,166 samples from normal and tumor tissues, we significantly expand the landscape of human long noncoding RNA with a high-quality atlas: RefLnc (Reference catalog of LncRNA). Powered by comprehensive annotation across multiple sources, RefLnc helps to pinpoint 275 novel intergenic lncRNAs correlated with sex, age or race as well as 369 novel ones associated with patient survival, clinical stage, tumor metastasis or recurrence. Integrated in a user-friendly online portal, the expanded catalog of human lncRNAs provides a valuable resource for investigating lncRNA function in both human biology and cancer development.
format Online
Article
Text
id pubmed-6735957
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-67359572020-08-18 An expanded landscape of human long noncoding RNA Jiang, Shuai Cheng, Si-Jin Ren, Li-Chen Wang, Qian Kang, Yu-Jian Ding, Yang Hou, Mei Yang, Xiao-Xu Lin, Yuan Liang, Nan Gao, Ge Nucleic Acids Res Data Resources and Analyses Long noncoding RNAs (lncRNAs) are emerging as key regulators of multiple essential biological processes involved in physiology and pathology. By analyzing the largest compendium of 14,166 samples from normal and tumor tissues, we significantly expand the landscape of human long noncoding RNA with a high-quality atlas: RefLnc (Reference catalog of LncRNA). Powered by comprehensive annotation across multiple sources, RefLnc helps to pinpoint 275 novel intergenic lncRNAs correlated with sex, age or race as well as 369 novel ones associated with patient survival, clinical stage, tumor metastasis or recurrence. Integrated in a user-friendly online portal, the expanded catalog of human lncRNAs provides a valuable resource for investigating lncRNA function in both human biology and cancer development. Oxford University Press 2019-09-05 2019-07-27 /pmc/articles/PMC6735957/ /pubmed/31350901 http://dx.doi.org/10.1093/nar/gkz621 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Data Resources and Analyses
Jiang, Shuai
Cheng, Si-Jin
Ren, Li-Chen
Wang, Qian
Kang, Yu-Jian
Ding, Yang
Hou, Mei
Yang, Xiao-Xu
Lin, Yuan
Liang, Nan
Gao, Ge
An expanded landscape of human long noncoding RNA
title An expanded landscape of human long noncoding RNA
title_full An expanded landscape of human long noncoding RNA
title_fullStr An expanded landscape of human long noncoding RNA
title_full_unstemmed An expanded landscape of human long noncoding RNA
title_short An expanded landscape of human long noncoding RNA
title_sort expanded landscape of human long noncoding rna
topic Data Resources and Analyses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735957/
https://www.ncbi.nlm.nih.gov/pubmed/31350901
http://dx.doi.org/10.1093/nar/gkz621
work_keys_str_mv AT jiangshuai anexpandedlandscapeofhumanlongnoncodingrna
AT chengsijin anexpandedlandscapeofhumanlongnoncodingrna
AT renlichen anexpandedlandscapeofhumanlongnoncodingrna
AT wangqian anexpandedlandscapeofhumanlongnoncodingrna
AT kangyujian anexpandedlandscapeofhumanlongnoncodingrna
AT dingyang anexpandedlandscapeofhumanlongnoncodingrna
AT houmei anexpandedlandscapeofhumanlongnoncodingrna
AT yangxiaoxu anexpandedlandscapeofhumanlongnoncodingrna
AT linyuan anexpandedlandscapeofhumanlongnoncodingrna
AT liangnan anexpandedlandscapeofhumanlongnoncodingrna
AT gaoge anexpandedlandscapeofhumanlongnoncodingrna
AT jiangshuai expandedlandscapeofhumanlongnoncodingrna
AT chengsijin expandedlandscapeofhumanlongnoncodingrna
AT renlichen expandedlandscapeofhumanlongnoncodingrna
AT wangqian expandedlandscapeofhumanlongnoncodingrna
AT kangyujian expandedlandscapeofhumanlongnoncodingrna
AT dingyang expandedlandscapeofhumanlongnoncodingrna
AT houmei expandedlandscapeofhumanlongnoncodingrna
AT yangxiaoxu expandedlandscapeofhumanlongnoncodingrna
AT linyuan expandedlandscapeofhumanlongnoncodingrna
AT liangnan expandedlandscapeofhumanlongnoncodingrna
AT gaoge expandedlandscapeofhumanlongnoncodingrna

Ejemplares similares