Dual role of N-acetyl-aspartyl-glutamate metabolism in cancer monitor and therapy

We uncovered the neurotransmitter N-acetyl-aspartyl-glutamate (NAAG) as a reservoir providing glutamate to promote cancer growth, and demonstrated that inhibition of NAAG hydrolysis by targeting glutamate carboxypeptidase II is a viable strategy for cancer therapy. Our study also suggests that NAAG...

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Detalles Bibliográficos
Autores principales: Asaka, Ryoichi, Le, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736126/
https://www.ncbi.nlm.nih.gov/pubmed/31528698
http://dx.doi.org/10.1080/23723556.2019.1627273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736126/
https://www.ncbi.nlm.nih.gov/pubmed/31528698
http://dx.doi.org/10.1080/23723556.2019.1627273

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