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Dual role of N-acetyl-aspartyl-glutamate metabolism in cancer monitor and therapy
We uncovered the neurotransmitter N-acetyl-aspartyl-glutamate (NAAG) as a reservoir providing glutamate to promote cancer growth, and demonstrated that inhibition of NAAG hydrolysis by targeting glutamate carboxypeptidase II is a viable strategy for cancer therapy. Our study also suggests that NAAG...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736126/ https://www.ncbi.nlm.nih.gov/pubmed/31528698 http://dx.doi.org/10.1080/23723556.2019.1627273 |