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A kinetochore-based ATM/ATR-independent DNA damage checkpoint maintains genomic integrity in trypanosomes

DNA damage-induced cell cycle checkpoints serve as surveillance mechanisms to maintain genomic stability, and are regulated by ATM/ATR-mediated signaling pathways that are conserved from yeast to humans. Trypanosoma brucei, an early divergent microbial eukaryote, lacks key components of the conventi...

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Detalles Bibliográficos
Autores principales:	Zhou, Qing, Pham, Kieu T M, Hu, Huiqing, Kurasawa, Yasuhiro, Li, Ziyin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736141/ https://www.ncbi.nlm.nih.gov/pubmed/31147720 http://dx.doi.org/10.1093/nar/gkz476

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