All over the place: deciphering HRAS signaling from different subcellular compartments

RAS (rat sarcoma virus oncogene homolog) oncogenes regulate fundamental biological processes through an ever-expanding signaling network. Using interaction proteomics, phosphoproteomics, transcriptomics, and integration of these datasets with a novel biostatistics approach, we have investigated Harv...

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Detalles Bibliográficos
Autores principales: Kolch, Walter, Matallanas, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736159/
https://www.ncbi.nlm.nih.gov/pubmed/31528689
http://dx.doi.org/10.1080/23723556.2019.1605821
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author Kolch, Walter
Matallanas, David
author_facet Kolch, Walter
Matallanas, David
author_sort Kolch, Walter
collection PubMed
description RAS (rat sarcoma virus oncogene homolog) oncogenes regulate fundamental biological processes through an ever-expanding signaling network. Using interaction proteomics, phosphoproteomics, transcriptomics, and integration of these datasets with a novel biostatistics approach, we have investigated Harvey-RAS (HRAS) signaling from different subcellular sites. The results reveal highly diversified signaling networks that regulate different aspects of HRAS functions.
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spelling pubmed-67361592020-05-20 All over the place: deciphering HRAS signaling from different subcellular compartments Kolch, Walter Matallanas, David Mol Cell Oncol Author's Views RAS (rat sarcoma virus oncogene homolog) oncogenes regulate fundamental biological processes through an ever-expanding signaling network. Using interaction proteomics, phosphoproteomics, transcriptomics, and integration of these datasets with a novel biostatistics approach, we have investigated Harvey-RAS (HRAS) signaling from different subcellular sites. The results reveal highly diversified signaling networks that regulate different aspects of HRAS functions. Taylor & Francis 2019-05-20 /pmc/articles/PMC6736159/ /pubmed/31528689 http://dx.doi.org/10.1080/23723556.2019.1605821 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Kolch, Walter
Matallanas, David
All over the place: deciphering HRAS signaling from different subcellular compartments
title All over the place: deciphering HRAS signaling from different subcellular compartments
title_full All over the place: deciphering HRAS signaling from different subcellular compartments
title_fullStr All over the place: deciphering HRAS signaling from different subcellular compartments
title_full_unstemmed All over the place: deciphering HRAS signaling from different subcellular compartments
title_short All over the place: deciphering HRAS signaling from different subcellular compartments
title_sort all over the place: deciphering hras signaling from different subcellular compartments
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736159/
https://www.ncbi.nlm.nih.gov/pubmed/31528689
http://dx.doi.org/10.1080/23723556.2019.1605821
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