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Gasdermins: novel mitochondrial pore-forming proteins
Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described. We recently demonstrated that some gasdermin proteins can also permeabilize the mitochondria to augment...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736162/ https://www.ncbi.nlm.nih.gov/pubmed/31528697 http://dx.doi.org/10.1080/23723556.2019.1621501 |
| _version_ | 1783450466753970176 |
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| author | Rogers, Corey Alnemri, Emad S. |
| author_facet | Rogers, Corey Alnemri, Emad S. |
| author_sort | Rogers, Corey |
| collection | PubMed |
| description | Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described. We recently demonstrated that some gasdermin proteins can also permeabilize the mitochondria to augment apoptotic signaling which may be important in the context of cancer and hearing loss. |
| format | Online Article Text |
| id | pubmed-6736162 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-67361622020-06-24 Gasdermins: novel mitochondrial pore-forming proteins Rogers, Corey Alnemri, Emad S. Mol Cell Oncol Author’s Views Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described. We recently demonstrated that some gasdermin proteins can also permeabilize the mitochondria to augment apoptotic signaling which may be important in the context of cancer and hearing loss. Taylor & Francis 2019-06-24 /pmc/articles/PMC6736162/ /pubmed/31528697 http://dx.doi.org/10.1080/23723556.2019.1621501 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
| spellingShingle | Author’s Views Rogers, Corey Alnemri, Emad S. Gasdermins: novel mitochondrial pore-forming proteins |
| title | Gasdermins: novel mitochondrial pore-forming proteins |
| title_full | Gasdermins: novel mitochondrial pore-forming proteins |
| title_fullStr | Gasdermins: novel mitochondrial pore-forming proteins |
| title_full_unstemmed | Gasdermins: novel mitochondrial pore-forming proteins |
| title_short | Gasdermins: novel mitochondrial pore-forming proteins |
| title_sort | gasdermins: novel mitochondrial pore-forming proteins |
| topic | Author’s Views |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736162/ https://www.ncbi.nlm.nih.gov/pubmed/31528697 http://dx.doi.org/10.1080/23723556.2019.1621501 |
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