At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1

Human papillomavirus (HPV) is recognized as a necessary, but insufficient cause of cervical cancer. Recent in vitro and in vivo evidence from our laboratory demonstrate that hyperactivation of yes-associated protein 1 (YAP1) is sufficient to induce cervical carcinogenesis. We found that synergism be...

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Detalles Bibliográficos
Autores principales: Wang, Cheng, Davis, John S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736164/
https://www.ncbi.nlm.nih.gov/pubmed/31528691
http://dx.doi.org/10.1080/23723556.2019.1612677
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author Wang, Cheng
Davis, John S
author_facet Wang, Cheng
Davis, John S
author_sort Wang, Cheng
collection PubMed
description Human papillomavirus (HPV) is recognized as a necessary, but insufficient cause of cervical cancer. Recent in vitro and in vivo evidence from our laboratory demonstrate that hyperactivation of yes-associated protein 1 (YAP1) is sufficient to induce cervical carcinogenesis. We found that synergism between hyperactivated YAP1 and high-risk HPV is a key driver of cervical cancer initiation and progression.
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spelling pubmed-67361642020-05-23 At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1 Wang, Cheng Davis, John S Mol Cell Oncol Commentary Human papillomavirus (HPV) is recognized as a necessary, but insufficient cause of cervical cancer. Recent in vitro and in vivo evidence from our laboratory demonstrate that hyperactivation of yes-associated protein 1 (YAP1) is sufficient to induce cervical carcinogenesis. We found that synergism between hyperactivated YAP1 and high-risk HPV is a key driver of cervical cancer initiation and progression. Taylor & Francis 2019-05-23 /pmc/articles/PMC6736164/ /pubmed/31528691 http://dx.doi.org/10.1080/23723556.2019.1612677 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Wang, Cheng
Davis, John S
At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1
title At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1
title_full At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1
title_fullStr At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1
title_full_unstemmed At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1
title_short At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1
title_sort at the center of cervical carcinogenesis: synergism between high-risk hpv and the hyperactivated yap1
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736164/
https://www.ncbi.nlm.nih.gov/pubmed/31528691
http://dx.doi.org/10.1080/23723556.2019.1612677
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