HectH9 hijacks glucose metabolism to fuel tumor growth

Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hong-Jen, He, Jiabei, Chan, Chia-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736202/
https://www.ncbi.nlm.nih.gov/pubmed/31528705
http://dx.doi.org/10.1080/23723556.2019.1644599
_version_ 1783450472738193408
author Lee, Hong-Jen
He, Jiabei
Chan, Chia-Hsin
author_facet Lee, Hong-Jen
He, Jiabei
Chan, Chia-Hsin
author_sort Lee, Hong-Jen
collection PubMed
description Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH9 is a new strategy to tackle metabolism-addicted tumors.
format Online
Article
Text
id pubmed-6736202
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-67362022020-07-24 HectH9 hijacks glucose metabolism to fuel tumor growth Lee, Hong-Jen He, Jiabei Chan, Chia-Hsin Mol Cell Oncol Author’s Views Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH9 is a new strategy to tackle metabolism-addicted tumors. Taylor & Francis 2019-07-24 /pmc/articles/PMC6736202/ /pubmed/31528705 http://dx.doi.org/10.1080/23723556.2019.1644599 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Lee, Hong-Jen
He, Jiabei
Chan, Chia-Hsin
HectH9 hijacks glucose metabolism to fuel tumor growth
title HectH9 hijacks glucose metabolism to fuel tumor growth
title_full HectH9 hijacks glucose metabolism to fuel tumor growth
title_fullStr HectH9 hijacks glucose metabolism to fuel tumor growth
title_full_unstemmed HectH9 hijacks glucose metabolism to fuel tumor growth
title_short HectH9 hijacks glucose metabolism to fuel tumor growth
title_sort hecth9 hijacks glucose metabolism to fuel tumor growth
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736202/
https://www.ncbi.nlm.nih.gov/pubmed/31528705
http://dx.doi.org/10.1080/23723556.2019.1644599
work_keys_str_mv AT leehongjen hecth9hijacksglucosemetabolismtofueltumorgrowth
AT hejiabei hecth9hijacksglucosemetabolismtofueltumorgrowth
AT chanchiahsin hecth9hijacksglucosemetabolismtofueltumorgrowth

Ejemplares similares