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HectH9 hijacks glucose metabolism to fuel tumor growth
Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2’s functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736202/ https://www.ncbi.nlm.nih.gov/pubmed/31528705 http://dx.doi.org/10.1080/23723556.2019.1644599 |