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Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis

OBJECTIVES: This study aimed to determine the effects of propolis on immune mediators and tissue histopathology in rats with L-arginine-induced acute pancreatitis (AP). METHODS: This study was conducted at Imam Abdulrahman Bin Faisal University, Dammam, Saudia Arabia between September and November 2...

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Autores principales: Al-Hariri, Mohammed T., Eldin, Tharwat G., Hashim, Tarek, Chathoth, Shahanas, Alswied, Abdullah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736264/
https://www.ncbi.nlm.nih.gov/pubmed/31538007
http://dx.doi.org/10.18295/squmj.2019.19.02.004
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author Al-Hariri, Mohammed T.
Eldin, Tharwat G.
Hashim, Tarek
Chathoth, Shahanas
Alswied, Abdullah
author_facet Al-Hariri, Mohammed T.
Eldin, Tharwat G.
Hashim, Tarek
Chathoth, Shahanas
Alswied, Abdullah
author_sort Al-Hariri, Mohammed T.
collection PubMed
description OBJECTIVES: This study aimed to determine the effects of propolis on immune mediators and tissue histopathology in rats with L-arginine-induced acute pancreatitis (AP). METHODS: This study was conducted at Imam Abdulrahman Bin Faisal University, Dammam, Saudia Arabia between September and November 2017. A total of 24 male albino Wistar rats were divided into three equal groups. Group one was the negative control, group two was the positive control (L-arginine-induced AP) and group three received treatment (L-arginineinduced AP and propolis). The rats in group three were treated with 100 mg/kg propolis for seven days after AP induction. Pancreatic tissue was evaluated histologically and levels of interleukin (IL)-6, IL-22 and IL-1β and tumour necrosis factor-alpha (TNF-α) were measured. RESULTS: Propolis reduced the quanitity of proinflammatory molecules (TNF-α, IL-1β and IL-6) in group three compared to group two, significantly increased the overall anti-inflammatory effect of IL-22 (P <0.005) and reduced interstitial inflammation and neutrophil cell infiltration of the pancreatic tissues. CONCLUSION: Propolis may exert a therapeutic effect in AP. Further studies are required to demonstrate the mechanisms of propolis in AP.
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spelling pubmed-67362642019-09-19 Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis Al-Hariri, Mohammed T. Eldin, Tharwat G. Hashim, Tarek Chathoth, Shahanas Alswied, Abdullah Sultan Qaboos Univ Med J Clinical & Basic Research OBJECTIVES: This study aimed to determine the effects of propolis on immune mediators and tissue histopathology in rats with L-arginine-induced acute pancreatitis (AP). METHODS: This study was conducted at Imam Abdulrahman Bin Faisal University, Dammam, Saudia Arabia between September and November 2017. A total of 24 male albino Wistar rats were divided into three equal groups. Group one was the negative control, group two was the positive control (L-arginine-induced AP) and group three received treatment (L-arginineinduced AP and propolis). The rats in group three were treated with 100 mg/kg propolis for seven days after AP induction. Pancreatic tissue was evaluated histologically and levels of interleukin (IL)-6, IL-22 and IL-1β and tumour necrosis factor-alpha (TNF-α) were measured. RESULTS: Propolis reduced the quanitity of proinflammatory molecules (TNF-α, IL-1β and IL-6) in group three compared to group two, significantly increased the overall anti-inflammatory effect of IL-22 (P <0.005) and reduced interstitial inflammation and neutrophil cell infiltration of the pancreatic tissues. CONCLUSION: Propolis may exert a therapeutic effect in AP. Further studies are required to demonstrate the mechanisms of propolis in AP. Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences 2019-05 2019-09-08 /pmc/articles/PMC6736264/ /pubmed/31538007 http://dx.doi.org/10.18295/squmj.2019.19.02.004 Text en © Copyright 2019, Sultan Qaboos University Medical Journal, All Rights Reserved This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nd/4.0/) .
spellingShingle Clinical & Basic Research
Al-Hariri, Mohammed T.
Eldin, Tharwat G.
Hashim, Tarek
Chathoth, Shahanas
Alswied, Abdullah
Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis
title Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis
title_full Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis
title_fullStr Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis
title_full_unstemmed Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis
title_short Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis
title_sort propolis modulates inflammatory mediators and improves histopathology in male rats with l-arginine-induced acute pancreatitis
topic Clinical & Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736264/
https://www.ncbi.nlm.nih.gov/pubmed/31538007
http://dx.doi.org/10.18295/squmj.2019.19.02.004
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