Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies

HIV envelope protein (Env) is the sole target of broadly neutralizing antibodies (BNAbs) that are capable of neutralizing diverse strains of HIV. While BNAbs develop spontaneously in a subset of HIV-infected patients, efforts to design an envelope protein-based immunogen to elicit broadly neutralizi...

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Detalles Bibliográficos
Autores principales: Zhu, Hong, Mathew, Elizabeth, Connelly, Sara M., Zuber, Jeffrey, Sullivan, Mark, Piepenbrink, Michael S., Kobie, James J., Dumont, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736307/
https://www.ncbi.nlm.nih.gov/pubmed/31504041
http://dx.doi.org/10.1371/journal.pone.0221550

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