Telomeres and sirtuins: at the end we meet again

Telomeres and sirtuins are independently implicated in causing disease and aging, but how they cooperate is not well understood. A recent study demonstrates that telomere shortening represses sirtuins and increasing sirtuin activity stabilizes telomeres and improves telomere-dependent disease, sugge...

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Detalles Bibliográficos
Autores principales: Amano, Hisayuki, Sahin, Ergun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736325/
https://www.ncbi.nlm.nih.gov/pubmed/31528700
http://dx.doi.org/10.1080/23723556.2019.1632613
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author Amano, Hisayuki
Sahin, Ergun
author_facet Amano, Hisayuki
Sahin, Ergun
author_sort Amano, Hisayuki
collection PubMed
description Telomeres and sirtuins are independently implicated in causing disease and aging, but how they cooperate is not well understood. A recent study demonstrates that telomere shortening represses sirtuins and increasing sirtuin activity stabilizes telomeres and improves telomere-dependent disease, suggesting that these two pathways are tightly intertwined.
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spelling pubmed-67363252020-07-07 Telomeres and sirtuins: at the end we meet again Amano, Hisayuki Sahin, Ergun Mol Cell Oncol Author’s Views Telomeres and sirtuins are independently implicated in causing disease and aging, but how they cooperate is not well understood. A recent study demonstrates that telomere shortening represses sirtuins and increasing sirtuin activity stabilizes telomeres and improves telomere-dependent disease, suggesting that these two pathways are tightly intertwined. Taylor & Francis 2019-07-07 /pmc/articles/PMC6736325/ /pubmed/31528700 http://dx.doi.org/10.1080/23723556.2019.1632613 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Amano, Hisayuki
Sahin, Ergun
Telomeres and sirtuins: at the end we meet again
title Telomeres and sirtuins: at the end we meet again
title_full Telomeres and sirtuins: at the end we meet again
title_fullStr Telomeres and sirtuins: at the end we meet again
title_full_unstemmed Telomeres and sirtuins: at the end we meet again
title_short Telomeres and sirtuins: at the end we meet again
title_sort telomeres and sirtuins: at the end we meet again
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736325/
https://www.ncbi.nlm.nih.gov/pubmed/31528700
http://dx.doi.org/10.1080/23723556.2019.1632613
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