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Modeling Structural Constraints on Protein Evolution via Side-Chain Conformational States

Few models of sequence evolution incorporate parameters describing protein structure, despite its high conservation, essential functional role and increasing availability. We present a structurally aware empirical substitution model for amino acid sequence evolution in which proteins are expressed u...

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Detalles Bibliográficos
Autores principales:	Perron, Umberto, Kozlov, Alexey M, Stamatakis, Alexandros, Goldman, Nick, Moal, Iain H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Methods
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736381/ https://www.ncbi.nlm.nih.gov/pubmed/31114882 http://dx.doi.org/10.1093/molbev/msz122

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