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p53 modifications: exquisite decorations of the powerful guardian

The last 40 years have witnessed how p53 rose from a viral binding protein to a central factor in both stress responses and tumor suppression. The exquisite regulation of p53 functions is of vital importance for cell fate decisions. Among the multiple layers of mechanisms controlling p53 function, p...

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Detalles Bibliográficos
Autores principales: Liu, Yanqing, Tavana, Omid, Gu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736412/
https://www.ncbi.nlm.nih.gov/pubmed/31282934
http://dx.doi.org/10.1093/jmcb/mjz060
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author Liu, Yanqing
Tavana, Omid
Gu, Wei
author_facet Liu, Yanqing
Tavana, Omid
Gu, Wei
author_sort Liu, Yanqing
collection PubMed
description The last 40 years have witnessed how p53 rose from a viral binding protein to a central factor in both stress responses and tumor suppression. The exquisite regulation of p53 functions is of vital importance for cell fate decisions. Among the multiple layers of mechanisms controlling p53 function, posttranslational modifications (PTMs) represent an efficient and precise way. Major p53 PTMs include phosphorylation, ubiquitination, acetylation, and methylation. Meanwhile, other PTMs like sumoylation, neddylation, O-GlcNAcylation, adenosine diphosphate (ADP)-ribosylation, hydroxylation, and β-hydroxybutyrylation are also shown to play various roles in p53 regulation. By independent action or interaction, PTMs affect p53 stability, conformation, localization, and binding partners. Deregulation of the PTM-related pathway is among the major causes of p53-associated developmental disorders or diseases, especially in cancers. This review focuses on the roles of different p53 modification types and shows how these modifications are orchestrated to produce various outcomes by modulating p53 activities or targeted to treat different diseases caused by p53 dysregulation.
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spelling pubmed-67364122019-09-16 p53 modifications: exquisite decorations of the powerful guardian Liu, Yanqing Tavana, Omid Gu, Wei J Mol Cell Biol Review The last 40 years have witnessed how p53 rose from a viral binding protein to a central factor in both stress responses and tumor suppression. The exquisite regulation of p53 functions is of vital importance for cell fate decisions. Among the multiple layers of mechanisms controlling p53 function, posttranslational modifications (PTMs) represent an efficient and precise way. Major p53 PTMs include phosphorylation, ubiquitination, acetylation, and methylation. Meanwhile, other PTMs like sumoylation, neddylation, O-GlcNAcylation, adenosine diphosphate (ADP)-ribosylation, hydroxylation, and β-hydroxybutyrylation are also shown to play various roles in p53 regulation. By independent action or interaction, PTMs affect p53 stability, conformation, localization, and binding partners. Deregulation of the PTM-related pathway is among the major causes of p53-associated developmental disorders or diseases, especially in cancers. This review focuses on the roles of different p53 modification types and shows how these modifications are orchestrated to produce various outcomes by modulating p53 activities or targeted to treat different diseases caused by p53 dysregulation. Oxford University Press 2019-08-16 /pmc/articles/PMC6736412/ /pubmed/31282934 http://dx.doi.org/10.1093/jmcb/mjz060 Text en © The Author(s) (2019). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Review
Liu, Yanqing
Tavana, Omid
Gu, Wei
p53 modifications: exquisite decorations of the powerful guardian
title p53 modifications: exquisite decorations of the powerful guardian
title_full p53 modifications: exquisite decorations of the powerful guardian
title_fullStr p53 modifications: exquisite decorations of the powerful guardian
title_full_unstemmed p53 modifications: exquisite decorations of the powerful guardian
title_short p53 modifications: exquisite decorations of the powerful guardian
title_sort p53 modifications: exquisite decorations of the powerful guardian
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736412/
https://www.ncbi.nlm.nih.gov/pubmed/31282934
http://dx.doi.org/10.1093/jmcb/mjz060
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