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Decontamination and Management of Contaminated Hair following a CBRN or HazMat Incident

This in vitro study evaluated the “triple protocol” of dry decontamination, the ladder pipe system (a method for gross decontamination), and technical decontamination for the decontamination of hair following chemical contamination. First, we assessed the efficacy of the 3 protocols, alone or in com...

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Autores principales: Matar, Hazem, Pinhal, Andreia, Amer, Nevine, Barrett, Mark, Thomas, Elliot, Hughes, Philip, Larner, Joanne, Chilcott, Robert P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736418/
https://www.ncbi.nlm.nih.gov/pubmed/31241158
http://dx.doi.org/10.1093/toxsci/kfz145
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author Matar, Hazem
Pinhal, Andreia
Amer, Nevine
Barrett, Mark
Thomas, Elliot
Hughes, Philip
Larner, Joanne
Chilcott, Robert P
author_facet Matar, Hazem
Pinhal, Andreia
Amer, Nevine
Barrett, Mark
Thomas, Elliot
Hughes, Philip
Larner, Joanne
Chilcott, Robert P
author_sort Matar, Hazem
collection PubMed
description This in vitro study evaluated the “triple protocol” of dry decontamination, the ladder pipe system (a method for gross decontamination), and technical decontamination for the decontamination of hair following chemical contamination. First, we assessed the efficacy of the 3 protocols, alone or in combination, on excised porcine skin and human hair contaminated with either methyl salicylate (MS), phorate (PHR), sodium fluoroacetate (SFA), or potassium cyanide (KCN). A second experiment investigated the residual hair contamination following decontamination with the triple protocol at different intervals postexposure. In a third experiment, hair decontaminated after exposure to MS or PHR was evaluated for off-gassing. Though skin decontamination was highly effective, a substantial proportion (20%–40%) of the lipophilic compounds (MS and PHR) remained within the hair. The more water-soluble contaminants (SFA and KCN) tended to form much smaller reservoirs within the hair. Interestingly, substantial off-gassing of MS, a medium volatility chemical, was detectable from triple-decontaminated hair up to 5 days postexposure. Overall, the decontamination strategies investigated were effective for the decontamination of skin, but less so for hair. These findings highlight the importance of contaminated hair serving as a source of potential secondary contamination by contact or inhalation. Therefore, consideration should be given to the removal of contaminated hair following exposure to toxic chemicals.
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spelling pubmed-67364182019-09-16 Decontamination and Management of Contaminated Hair following a CBRN or HazMat Incident Matar, Hazem Pinhal, Andreia Amer, Nevine Barrett, Mark Thomas, Elliot Hughes, Philip Larner, Joanne Chilcott, Robert P Toxicol Sci Regulatory Science, Risk Assessment and Decision Making This in vitro study evaluated the “triple protocol” of dry decontamination, the ladder pipe system (a method for gross decontamination), and technical decontamination for the decontamination of hair following chemical contamination. First, we assessed the efficacy of the 3 protocols, alone or in combination, on excised porcine skin and human hair contaminated with either methyl salicylate (MS), phorate (PHR), sodium fluoroacetate (SFA), or potassium cyanide (KCN). A second experiment investigated the residual hair contamination following decontamination with the triple protocol at different intervals postexposure. In a third experiment, hair decontaminated after exposure to MS or PHR was evaluated for off-gassing. Though skin decontamination was highly effective, a substantial proportion (20%–40%) of the lipophilic compounds (MS and PHR) remained within the hair. The more water-soluble contaminants (SFA and KCN) tended to form much smaller reservoirs within the hair. Interestingly, substantial off-gassing of MS, a medium volatility chemical, was detectable from triple-decontaminated hair up to 5 days postexposure. Overall, the decontamination strategies investigated were effective for the decontamination of skin, but less so for hair. These findings highlight the importance of contaminated hair serving as a source of potential secondary contamination by contact or inhalation. Therefore, consideration should be given to the removal of contaminated hair following exposure to toxic chemicals. Oxford University Press 2019-09 2019-06-26 /pmc/articles/PMC6736418/ /pubmed/31241158 http://dx.doi.org/10.1093/toxsci/kfz145 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of the Society of Toxicology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Regulatory Science, Risk Assessment and Decision Making
Matar, Hazem
Pinhal, Andreia
Amer, Nevine
Barrett, Mark
Thomas, Elliot
Hughes, Philip
Larner, Joanne
Chilcott, Robert P
Decontamination and Management of Contaminated Hair following a CBRN or HazMat Incident
title Decontamination and Management of Contaminated Hair following a CBRN or HazMat Incident
title_full Decontamination and Management of Contaminated Hair following a CBRN or HazMat Incident
title_fullStr Decontamination and Management of Contaminated Hair following a CBRN or HazMat Incident
title_full_unstemmed Decontamination and Management of Contaminated Hair following a CBRN or HazMat Incident
title_short Decontamination and Management of Contaminated Hair following a CBRN or HazMat Incident
title_sort decontamination and management of contaminated hair following a cbrn or hazmat incident
topic Regulatory Science, Risk Assessment and Decision Making
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736418/
https://www.ncbi.nlm.nih.gov/pubmed/31241158
http://dx.doi.org/10.1093/toxsci/kfz145
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