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A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
OBJECTIVE: The present study investigated the prognosis value of preoperative fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with local advanced gastric cancer (LAGC). METHODS: In total, 144 patients [median age 63 (range: 48−80) years old] with LAGC u...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736658/ https://www.ncbi.nlm.nih.gov/pubmed/31564806 http://dx.doi.org/10.21147/j.issn.1000-9604.2019.04.07 |
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author | Song, Jinling Li, Zhongwu Chen, Puyun Yu, Jiangyuan Wang, Feng Yang, Zhi Wang, Xuejuan |
author_facet | Song, Jinling Li, Zhongwu Chen, Puyun Yu, Jiangyuan Wang, Feng Yang, Zhi Wang, Xuejuan |
author_sort | Song, Jinling |
collection | PubMed |
description | OBJECTIVE: The present study investigated the prognosis value of preoperative fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with local advanced gastric cancer (LAGC). METHODS: In total, 144 patients [median age 63 (range: 48−80) years old] with LAGC underwent(18)F-FDG PET/CT prior to any treatment. The maximum standardized uptake values (SUV(max)), mean standardized uptake values (SUV(mean)), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of the primary lesion were measured on PET/CT and correlated with clinicopathological features and survival. RESULTS: Significant differences in SUV(mean), SUV(max), MTV and TLG were found according to Lauren’s classification, histologic grade and T category (P<0.05). During the 26.5-month follow-up, 51 (35.4%) patients died and 70 (48.6%) exhibited disease progression. The optimal thresholds of MTV and TLG were 15.1 cm(3) and 47.3 cm(3), respectively. The 3-year progression-free survival (PFS) and overall survival (OS) for patients with high TLG values were 30% and 38% compared to 38% and 47% for low TLG values, respectively (P<0.05). Univariate and multifactor analyses demonstrated that lymph node metastasis and T stage were independent prognostic factors for PFS; T stage, histologic grade and TLG were independent prognostic factors for OS (P<0.05). Molecular markers had no relationship with patient’s outcomes. CONCLUSIONS: Metabolic activity of primary gastric tumors from (18)F-FDG PET/CT is a prognostic factor in patients with LAGC. |
format | Online Article Text |
id | pubmed-6736658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-67366582019-09-27 A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer Song, Jinling Li, Zhongwu Chen, Puyun Yu, Jiangyuan Wang, Feng Yang, Zhi Wang, Xuejuan Chin J Cancer Res Original Article OBJECTIVE: The present study investigated the prognosis value of preoperative fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with local advanced gastric cancer (LAGC). METHODS: In total, 144 patients [median age 63 (range: 48−80) years old] with LAGC underwent(18)F-FDG PET/CT prior to any treatment. The maximum standardized uptake values (SUV(max)), mean standardized uptake values (SUV(mean)), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of the primary lesion were measured on PET/CT and correlated with clinicopathological features and survival. RESULTS: Significant differences in SUV(mean), SUV(max), MTV and TLG were found according to Lauren’s classification, histologic grade and T category (P<0.05). During the 26.5-month follow-up, 51 (35.4%) patients died and 70 (48.6%) exhibited disease progression. The optimal thresholds of MTV and TLG were 15.1 cm(3) and 47.3 cm(3), respectively. The 3-year progression-free survival (PFS) and overall survival (OS) for patients with high TLG values were 30% and 38% compared to 38% and 47% for low TLG values, respectively (P<0.05). Univariate and multifactor analyses demonstrated that lymph node metastasis and T stage were independent prognostic factors for PFS; T stage, histologic grade and TLG were independent prognostic factors for OS (P<0.05). Molecular markers had no relationship with patient’s outcomes. CONCLUSIONS: Metabolic activity of primary gastric tumors from (18)F-FDG PET/CT is a prognostic factor in patients with LAGC. AME Publishing Company 2019-08 /pmc/articles/PMC6736658/ /pubmed/31564806 http://dx.doi.org/10.21147/j.issn.1000-9604.2019.04.07 Text en Copyright © 2019 Chinese Journal of Cancer Research. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Original Article Song, Jinling Li, Zhongwu Chen, Puyun Yu, Jiangyuan Wang, Feng Yang, Zhi Wang, Xuejuan A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer |
title | A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
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title_full | A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
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title_fullStr | A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
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title_full_unstemmed | A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
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title_short | A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
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title_sort | (18)fdg pet/ct-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736658/ https://www.ncbi.nlm.nih.gov/pubmed/31564806 http://dx.doi.org/10.21147/j.issn.1000-9604.2019.04.07 |
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