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A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer

OBJECTIVE: The present study investigated the prognosis value of preoperative fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with local advanced gastric cancer (LAGC). METHODS: In total, 144 patients [median age 63 (range: 48−80) years old] with LAGC u...

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Autores principales: Song, Jinling, Li, Zhongwu, Chen, Puyun, Yu, Jiangyuan, Wang, Feng, Yang, Zhi, Wang, Xuejuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736658/
https://www.ncbi.nlm.nih.gov/pubmed/31564806
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.04.07
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author Song, Jinling
Li, Zhongwu
Chen, Puyun
Yu, Jiangyuan
Wang, Feng
Yang, Zhi
Wang, Xuejuan
author_facet Song, Jinling
Li, Zhongwu
Chen, Puyun
Yu, Jiangyuan
Wang, Feng
Yang, Zhi
Wang, Xuejuan
author_sort Song, Jinling
collection PubMed
description OBJECTIVE: The present study investigated the prognosis value of preoperative fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with local advanced gastric cancer (LAGC). METHODS: In total, 144 patients [median age 63 (range: 48−80) years old] with LAGC underwent(18)F-FDG PET/CT prior to any treatment. The maximum standardized uptake values (SUV(max)), mean standardized uptake values (SUV(mean)), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of the primary lesion were measured on PET/CT and correlated with clinicopathological features and survival. RESULTS: Significant differences in SUV(mean), SUV(max), MTV and TLG were found according to Lauren’s classification, histologic grade and T category (P<0.05). During the 26.5-month follow-up, 51 (35.4%) patients died and 70 (48.6%) exhibited disease progression. The optimal thresholds of MTV and TLG were 15.1 cm(3) and 47.3 cm(3), respectively. The 3-year progression-free survival (PFS) and overall survival (OS) for patients with high TLG values were 30% and 38% compared to 38% and 47% for low TLG values, respectively (P<0.05). Univariate and multifactor analyses demonstrated that lymph node metastasis and T stage were independent prognostic factors for PFS; T stage, histologic grade and TLG were independent prognostic factors for OS (P<0.05). Molecular markers had no relationship with patient’s outcomes. CONCLUSIONS: Metabolic activity of primary gastric tumors from (18)F-FDG PET/CT is a prognostic factor in patients with LAGC.
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spelling pubmed-67366582019-09-27 A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer Song, Jinling Li, Zhongwu Chen, Puyun Yu, Jiangyuan Wang, Feng Yang, Zhi Wang, Xuejuan Chin J Cancer Res Original Article OBJECTIVE: The present study investigated the prognosis value of preoperative fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with local advanced gastric cancer (LAGC). METHODS: In total, 144 patients [median age 63 (range: 48−80) years old] with LAGC underwent(18)F-FDG PET/CT prior to any treatment. The maximum standardized uptake values (SUV(max)), mean standardized uptake values (SUV(mean)), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of the primary lesion were measured on PET/CT and correlated with clinicopathological features and survival. RESULTS: Significant differences in SUV(mean), SUV(max), MTV and TLG were found according to Lauren’s classification, histologic grade and T category (P<0.05). During the 26.5-month follow-up, 51 (35.4%) patients died and 70 (48.6%) exhibited disease progression. The optimal thresholds of MTV and TLG were 15.1 cm(3) and 47.3 cm(3), respectively. The 3-year progression-free survival (PFS) and overall survival (OS) for patients with high TLG values were 30% and 38% compared to 38% and 47% for low TLG values, respectively (P<0.05). Univariate and multifactor analyses demonstrated that lymph node metastasis and T stage were independent prognostic factors for PFS; T stage, histologic grade and TLG were independent prognostic factors for OS (P<0.05). Molecular markers had no relationship with patient’s outcomes. CONCLUSIONS: Metabolic activity of primary gastric tumors from (18)F-FDG PET/CT is a prognostic factor in patients with LAGC. AME Publishing Company 2019-08 /pmc/articles/PMC6736658/ /pubmed/31564806 http://dx.doi.org/10.21147/j.issn.1000-9604.2019.04.07 Text en Copyright © 2019 Chinese Journal of Cancer Research. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Original Article
Song, Jinling
Li, Zhongwu
Chen, Puyun
Yu, Jiangyuan
Wang, Feng
Yang, Zhi
Wang, Xuejuan
A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
title A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
title_full A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
title_fullStr A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
title_full_unstemmed A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
title_short A (18)FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
title_sort (18)fdg pet/ct-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736658/
https://www.ncbi.nlm.nih.gov/pubmed/31564806
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.04.07
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