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Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China
OBJECTIVE: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus (HPV) infection in China and the vision of screen-and-treat strategies in low- and middle-income countries (LMICs). Considerations of combining type-specific prevalen...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736663/ https://www.ncbi.nlm.nih.gov/pubmed/31564809 http://dx.doi.org/10.21147/j.issn.1000-9604.2019.04.10 |
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author | Zhao, Shuang Zhao, Xuelian Hu, Shangying Lu, Jessica Duan, Xianzhi Zhang, Xun Chen, Feng Zhao, Fanghui |
author_facet | Zhao, Shuang Zhao, Xuelian Hu, Shangying Lu, Jessica Duan, Xianzhi Zhang, Xun Chen, Feng Zhao, Fanghui |
author_sort | Zhao, Shuang |
collection | PubMed |
description | OBJECTIVE: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus (HPV) infection in China and the vision of screen-and-treat strategies in low- and middle-income countries (LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North China. METHODS: A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction (PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus (HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method. RESULTS: A total of 22.2% (2,112/9,526) of women were HR-HPV positive and HPV52 (21.7%) was the most common HR-HPV genotype, followed by HPV58 (18.2%), HPV53 (18.2%) and HPV16 (16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia (CIN)1 were HPV16 (36.7%), HPV58 (20.4%), HPV56 (15.3%). Among CIN2+, the most frequent genotypes were HPV16 (75.6%), HPV52 (17.8%), HPV58 (16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions, and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions. CONCLUSIONS: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population. |
format | Online Article Text |
id | pubmed-6736663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-67366632019-09-27 Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China Zhao, Shuang Zhao, Xuelian Hu, Shangying Lu, Jessica Duan, Xianzhi Zhang, Xun Chen, Feng Zhao, Fanghui Chin J Cancer Res Original Article OBJECTIVE: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus (HPV) infection in China and the vision of screen-and-treat strategies in low- and middle-income countries (LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North China. METHODS: A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction (PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus (HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method. RESULTS: A total of 22.2% (2,112/9,526) of women were HR-HPV positive and HPV52 (21.7%) was the most common HR-HPV genotype, followed by HPV58 (18.2%), HPV53 (18.2%) and HPV16 (16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia (CIN)1 were HPV16 (36.7%), HPV58 (20.4%), HPV56 (15.3%). Among CIN2+, the most frequent genotypes were HPV16 (75.6%), HPV52 (17.8%), HPV58 (16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions, and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions. CONCLUSIONS: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population. AME Publishing Company 2019-08 /pmc/articles/PMC6736663/ /pubmed/31564809 http://dx.doi.org/10.21147/j.issn.1000-9604.2019.04.10 Text en Copyright © 2019 Chinese Journal of Cancer Research. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Original Article Zhao, Shuang Zhao, Xuelian Hu, Shangying Lu, Jessica Duan, Xianzhi Zhang, Xun Chen, Feng Zhao, Fanghui Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China |
title | Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China |
title_full | Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China |
title_fullStr | Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China |
title_full_unstemmed | Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China |
title_short | Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China |
title_sort | distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural north china |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736663/ https://www.ncbi.nlm.nih.gov/pubmed/31564809 http://dx.doi.org/10.21147/j.issn.1000-9604.2019.04.10 |
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