Cargando…

Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice.

Approximately 15–40% of all cancers develop metastases in the central nervous system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on monoclonal antibodies are widely successful, yet have limited efficacy against CNS metastases, owing to the low levels of the drug re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wen, Jing, Wu, Di, Qin, Meng, Liu, Chaoyong, Wang, Lan, Xu, Duo, Vinters, Harry V., Liu, Yang, Kranz, Emiko, Guan, Xin, Sun, Guibo, Sun, Xiaobo, Lee, YooJin, Martinez-Maza, Otoniel, Widney, Daniel, Lu, Yunfeng, Chen, Irvin SY., Kamata, Masakazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736720/ https://www.ncbi.nlm.nih.gov/pubmed/31384008 http://dx.doi.org/10.1038/s41551-019-0434-z

Ejemplares similares

Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates
por: Qin, Meng, et al.
Publicado: (2020)

Efficacy of Antibodies Targeting TfR1 in Xenograft Mouse Models of AIDS-Related Non-Hodgkin Lymphoma
por: Daniels-Wells, Tracy R., et al.
Publicado: (2023)

Nanoencapsulated rituximab mediates superior cellular immunity against metastatic B-cell lymphoma in a complement competent humanized mouse model
por: Wen, Jing, et al.
Publicado: (2021)

Efficient derivation of chimeric-antigen receptor-modified T(SCM) cells
por: Kranz, Emiko, et al.
Publicado: (2022)

Elevated serum levels of CXCL13 precede HIV-associated non-Hodgkin’s lymphoma
por: Hussain, Shehnaz K, et al.
Publicado: (2010)

Modulation of Gene Expression by Polymer Nanocapsule Delivery of DNA Cassettes Encoding Small RNAs
por: Yan, Ming, et al.
Publicado: (2015)

Serum levels of several molecules that are associated with B cell activation and inflammation are elevated in AIDS-associated non-Hodgkin’s lymphoma (AIDS-NHL) and predict response to treatment
por: Epeldegui, Marta, et al.
Publicado: (2012)

Specific Elimination of Latently HIV-1 Infected Cells Using HIV-1 Protease-Sensitive Toxin Nanocapsules
por: Wen, Jing, et al.
Publicado: (2016)

Reassessing the Role of APOBEC3G in Human Immunodeficiency Virus Type 1 Infection of Quiescent CD4+ T-Cells
por: Kamata, Masakazu, et al.
Publicado: (2009)

Levels of Murine, but Not Human, CXCL13 Are Greatly Elevated in NOD-SCID Mice Bearing the AIDS-Associated Burkitt Lymphoma Cell Line, 2F7
por: Widney, Daniel P., et al.
Publicado: (2013)

Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-associated non-Hodgkin's lymphoma
por: Widney, DP, et al.
Publicado: (2009)

Live Cell Monitoring of hiPSC Generation and Differentiation Using Differential Expression of Endogenous microRNAs
por: Kamata, Masakazu, et al.
Publicado: (2010)

Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma
por: Widney, Daniel P., et al.
Publicado: (2010)

Unilateral hemispheric primary angiitis of the central nervous system
por: Ho, Michael G., et al.
Publicado: (2011)

LSCplus: a fast solution for improving long read accuracy by short read alignment
por: Hu, Ruifeng, et al.
Publicado: (2016)

Post-transplantation primary central nervous system lymphoma: A case report and review of the literature
por: Chou, Arthur P., et al.
Publicado: (2011)

Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4/DUSP22 rearrangement
por: Magaki, Shino, et al.
Publicado: (2021)

TarNet: An Evidence-Based Database for Natural Medicine Research
por: Hu, Ruifeng, et al.
Publicado: (2016)

Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5
por: Shimizu, Saki, et al.
Publicado: (2009)

Uterine leiomyosarcoma with central nervous system metastases
por: Abrahão, Carina Meira, et al.
Publicado: (2015)

Cytokine Landscape in Central Nervous System Metastases
por: Marin, Julie, et al.
Publicado: (2022)

Cryptoporus volvatus Extract Inhibits Influenza Virus Replication In Vitro and In Vivo
por: Gao, Li, et al.
Publicado: (2014)

Effects of Platycodin D on Proliferation, Apoptosis and PI3K/Akt Signal Pathway of Human Glioma U251 Cells
por: Xu, Chong, et al.
Publicado: (2014)

Ginsenoside Compound K Attenuates Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation via Autophagy Induction and Modulating NF-κB, p38, and JNK MAPK Signaling
por: Lu, Shan, et al.
Publicado: (2020)

Targeting Calcium Homeostasis in Myocardial Ischemia/Reperfusion Injury: An Overview of Regulatory Mechanisms and Therapeutic Reagents
por: Wang, Ruiying, et al.
Publicado: (2020)

Development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis
por: Qiang, Weijie, et al.
Publicado: (2020)

Mechanism overview and target mining of atherosclerosis: Endothelial cell injury in atherosclerosis is regulated by glycolysis (Review)
por: Wang, Ruiying, et al.
Publicado: (2021)

Effect of Panax notoginseng Saponins and Major Anti-Obesity Components on Weight Loss
por: Zhang, Xuelian, et al.
Publicado: (2021)

Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes
por: Zhang, Chenyang, et al.
Publicado: (2020)

Classical Active Ingredients and Extracts of Chinese Herbal Medicines: Pharmacokinetics, Pharmacodynamics, and Molecular Mechanisms for Ischemic Stroke
por: Zhu, Ting, et al.
Publicado: (2021)

Current Progress in Delineating the Roles of Pseudokinase TRIB1 in Controlling Human Diseases
por: Zhang, Xuelian, et al.
Publicado: (2021)

Trib1 deficiency causes brown adipose respiratory chain depletion and mitochondrial disorder
por: Zhang, Xuelian, et al.
Publicado: (2021)

Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges
por: Zhang, Shuxia, et al.
Publicado: (2021)

Myricitrin Attenuates High Glucose-Induced Apoptosis through Activating Akt-Nrf2 Signaling in H9c2 Cardiomyocytes
por: Zhang, Bin, et al.
Publicado: (2016)

Overexpression of MicroRNAs from the miR-17-92 Paralog Clusters in AIDS-Related Non-Hodgkin's Lymphomas
por: Thapa, Dharma R., et al.
Publicado: (2011)

Deep Sequencing Reveals Low Incidence of Endogenous LINE-1 Retrotransposition in Human Induced Pluripotent Stem Cells
por: Arokium, Hubert, et al.
Publicado: (2014)

Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERK/P53 Pathway
por: Sun, Jing, et al.
Publicado: (2016)

Ginsenoside Rg1 prevents early diabetic retinopathy via reducing retinal ganglion cell layer and inner nuclear layer cell apoptosis in db/db mice
por: Gao, Ye, et al.
Publicado: (2020)

Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stress–induced mitochondrial injury
por: Yu, Yingli, et al.
Publicado: (2021)

An Autopsy Case of Epstein-Barr Virus–Associated Diffuse Large B-Cell Lymphoma of the Central Nervous System in an Immunocompromised Host
por: Park, Sun-Young, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_i4fl7598avssvm0rup360e5ule