Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI

Lung cancer diagnosis via imaging may be confounded by the presence of indolent infectious nodules in imaging studies. This issue is pervasive in the southwestern US where coccidioidomycosis (Valley Fever) is endemic. AcidoCEST MRI is a noninvasive imaging method that quantifies the extracellular pH...

Descripción completa

Detalles Bibliográficos
Autores principales: Lindeman, Leila R., Jones, Kyle M., High, Rachel A., Howison, Christine M., Shubitz, Lisa F., Pagel, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736855/
https://www.ncbi.nlm.nih.gov/pubmed/31506562
http://dx.doi.org/10.1038/s41598-019-49514-1
_version_ 1783450561843036160
author Lindeman, Leila R.
Jones, Kyle M.
High, Rachel A.
Howison, Christine M.
Shubitz, Lisa F.
Pagel, Mark D.
author_facet Lindeman, Leila R.
Jones, Kyle M.
High, Rachel A.
Howison, Christine M.
Shubitz, Lisa F.
Pagel, Mark D.
author_sort Lindeman, Leila R.
collection PubMed
description Lung cancer diagnosis via imaging may be confounded by the presence of indolent infectious nodules in imaging studies. This issue is pervasive in the southwestern US where coccidioidomycosis (Valley Fever) is endemic. AcidoCEST MRI is a noninvasive imaging method that quantifies the extracellular pH (pHe) of tissues in vivo, allowing tumor acidosis to be used as a diagnostic biomarker. Using murine models of lung adenocarcinoma and coccidoidomycosis, we found that average lesion pHe differed significantly between tumors and granulomas. Our study shows that acidoCEST MRI is a promising tool for improving the specificity of lung cancer diagnosis.
format Online
Article
Text
id pubmed-6736855
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-67368552019-09-20 Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI Lindeman, Leila R. Jones, Kyle M. High, Rachel A. Howison, Christine M. Shubitz, Lisa F. Pagel, Mark D. Sci Rep Article Lung cancer diagnosis via imaging may be confounded by the presence of indolent infectious nodules in imaging studies. This issue is pervasive in the southwestern US where coccidioidomycosis (Valley Fever) is endemic. AcidoCEST MRI is a noninvasive imaging method that quantifies the extracellular pH (pHe) of tissues in vivo, allowing tumor acidosis to be used as a diagnostic biomarker. Using murine models of lung adenocarcinoma and coccidoidomycosis, we found that average lesion pHe differed significantly between tumors and granulomas. Our study shows that acidoCEST MRI is a promising tool for improving the specificity of lung cancer diagnosis. Nature Publishing Group UK 2019-09-10 /pmc/articles/PMC6736855/ /pubmed/31506562 http://dx.doi.org/10.1038/s41598-019-49514-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lindeman, Leila R.
Jones, Kyle M.
High, Rachel A.
Howison, Christine M.
Shubitz, Lisa F.
Pagel, Mark D.
Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI
title Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI
title_full Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI
title_fullStr Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI
title_full_unstemmed Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI
title_short Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI
title_sort differentiating lung cancer and infection based on measurements of extracellular ph with acidocest mri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736855/
https://www.ncbi.nlm.nih.gov/pubmed/31506562
http://dx.doi.org/10.1038/s41598-019-49514-1
work_keys_str_mv AT lindemanleilar differentiatinglungcancerandinfectionbasedonmeasurementsofextracellularphwithacidocestmri
AT joneskylem differentiatinglungcancerandinfectionbasedonmeasurementsofextracellularphwithacidocestmri
AT highrachela differentiatinglungcancerandinfectionbasedonmeasurementsofextracellularphwithacidocestmri
AT howisonchristinem differentiatinglungcancerandinfectionbasedonmeasurementsofextracellularphwithacidocestmri
AT shubitzlisaf differentiatinglungcancerandinfectionbasedonmeasurementsofextracellularphwithacidocestmri
AT pagelmarkd differentiatinglungcancerandinfectionbasedonmeasurementsofextracellularphwithacidocestmri

Ejemplares similares