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Characterization of a novel LQT3 variant with a selective efficacy of mexiletine treatment
Pathogenic variants in the human SCN5A gene encoding the a-subunit of the principle Na(+) channel (Nav1.5) are associated with long QT syndrome (LQTS) 3. LQT3 patients display variable responses to Na(+) channel blockers demanding for the development of variant-specific therapeutic strategies. Here...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736863/ https://www.ncbi.nlm.nih.gov/pubmed/31506521 http://dx.doi.org/10.1038/s41598-019-49450-0 |