Cargando…

Prothrombin, alone or in complex concentrates or plasma, reduces bleeding in a mouse model of blood exchange-induced coagulopathy

Prothrombin complex concentrates (PCC) are fractionated plasma protein drugs that reverse warfarin anticoagulation. PCC may control more general bleeding. We sought to identify the dominant procoagulant factor in PCC in vivo. We tested PCC or coagulation factor (F) treatment in CD1 mice made coagulo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eltringham-Smith, Louise J., Yu, Ruoying, Qadri, Syed M., Wang, Yiming, Bhakta, Varsha, Pryzdial, Edward L., Crosby, Jeffrey R., Ni, Heyu, Sheffield, William P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736877/ https://www.ncbi.nlm.nih.gov/pubmed/31506556 http://dx.doi.org/10.1038/s41598-019-49552-9

Ejemplares similares

Correction of haemorrhagic shock-associated coagulopathy and impaired haemostasis by plasma, prothrombin complex concentrates or an activated protein C-targeted DNA aptamer in mice
por: Eltringham-Smith, Louise J., et al.
Publicado: (2023)

Using of prothrombin complex concentrate in patients with trauma-induced coagulopathy
por: Tarabrin, O, et al.
Publicado: (2015)

A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss
por: Sheffield, William P., et al.
Publicado: (2018)

Addition of a sequence from α(2)-antiplasmin transforms human serum albumin into a blood clot component that speeds clot lysis
por: Sheffield, William P, et al.
Publicado: (2009)

Prothrombin Complex Concentrates for Coagulopathy in Liver Disease: Single‐Center, Clinical Experience in 105 Patients
por: Drebes, Anja, et al.
Publicado: (2019)

Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses
por: Hannadjas, Ioannis, et al.
Publicado: (2023)

The effect of fibrinogen and prothrombin complex concentrate on dilutional coagulopathy in a porcine model of uncontrolled hemorrhagic shock
por: Fries, D, et al.
Publicado: (2005)

Comparison of prothrombin complex concentrate and fresh frozen plasma on thrombin generation and hemorrhage in experimental dilutional coagulopathy
por: Dickneite, G, et al.
Publicado: (2008)

Prothrombin complex concentrate vs fresh frozen plasma for reversal of dilutional coagulopathy in a porcine trauma model
por: Dickneite, G., et al.
Publicado: (2009)

Activated prothrombin complex concentrate factor VIII inhibitor bypassing activity (FEIBA) for the reversal of warfarin-induced coagulopathy
por: Wójcik, Cezary, et al.
Publicado: (2009)

Comparing prothrombin complex concentrate and fresh frozen plasma with blood viscosity characteristics in patients with trauma-induced coagulopathy
por: Tarabrin, O, et al.
Publicado: (2015)

Acquired deficiency of prothrombin complex coagulation factors in major bleeding is a therapeutic indication of 4‐factor prothrombin complex concentrates
por: Wiedermann, Christian J.
Publicado: (2020)

Prothrombin complex concentrate in the management of major bleeding induced by oral anticoagulant therapy
por: AlSheef, Mohammed, et al.
Publicado: (2022)

Efficacy of Prothrombin Complex Concentrate Treatment in Patients with Liver Coagulopathy Who Underwent Various Invasive Hepatobiliary and Gastrointestinal Procedures
por: Lesmana, Cosmas Rinaldi A., et al.
Publicado: (2016)

Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa
por: Donkor, David A., et al.
Publicado: (2017)

Prothrombin Complex Concentrate in Liver Transplant Surgery: Correction of Therapeutic Anticoagulation and the Coagulopathy of End-Stage Liver Disease: Case Series
por: Marshall, Scarlett V., et al.
Publicado: (2020)

Activated Prothrombin Complex Concentrate for coagulopathy reversal secondary to ischemic hepatic injury due to cardiac tamponade: A case report
por: Mitwally, Hassan, et al.
Publicado: (2021)

Prophylactic fresh frozen plasma versus prothrombin complex concentrate for preprocedural management of the coagulopathy of liver disease: A systematic review
por: Evans, Christina R., et al.
Publicado: (2022)

Three- versus four-factor prothrombin complex concentrate for the reversal of warfarin-induced bleeding
por: Holt, Tara, et al.
Publicado: (2018)

The impact of prothrombin complex concentrates when treating DOAC-associated bleeding: a review
por: Hoffman, Maureane, et al.
Publicado: (2018)

Effectiveness of prothrombin complex concentrate for the treatment of bleeding: A systematic review and meta‐analysis
por: van den Brink, Daan P., et al.
Publicado: (2020)

In Vivo Clearance of Alpha-1 Acid Glycoprotein Is Influenced by the Extent of Its N-Linked Glycosylation and by Its Interaction with the Vessel Wall
por: McCurdy, Teresa R., et al.
Publicado: (2012)

Comparison of Methods for the Purification of Alpha-1 Acid Glycoprotein from Human Plasma
por: McCurdy, Teresa R., et al.
Publicado: (2011)

Management of Coagulopathy in Bleeding Patients
por: Hofer, Stefan, et al.
Publicado: (2021)

Outcomes of 4-factor Prothrombin Complex Concentrate in Patients With Liver Disease and Nonvitamin K Antagonist-Related Coagulopathy: A Retrospective Study
por: Dodhiawala, Paarth B., et al.
Publicado: (2023)

Prothrombin complex concentrate mitigates diffuse bleeding after cardiopulmonary bypass in a porcine model
por: Kaspereit, F., et al.
Publicado: (2010)

Management of the Bleeding Patient Receiving New Oral Anticoagulants: A Role for Prothrombin Complex Concentrates
por: Baumann Kreuziger, Lisa M., et al.
Publicado: (2014)

Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery
por: Cappabianca, Giangiuseppe, et al.
Publicado: (2016)

Efficacy and safety of activated prothrombin complex concentrate for the reversal of vitamin K antagonist major bleeding
por: Sheikh-Taha, Marwan, et al.
Publicado: (2022)

Thromboembolism after treatment with 4-factor prothrombin complex concentrate or plasma for warfarin-related bleeding
por: Go, Alan S., et al.
Publicado: (2022)

Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin
por: Qadri, Syed M., et al.
Publicado: (2016)

Four-factor prothrombin complex concentrate improves thrombin generation and prothrombin time in patients with bleeding complications related to rivaroxaban: a single-center pilot trial
por: Schenk, Bettina, et al.
Publicado: (2018)

COVID-19 coagulopathy, thrombosis, and bleeding
por: Chan, Noel C., et al.
Publicado: (2020)

PROTHROMBIN DEFICIENCY THE CAUSE OF BLEEDING IN BILE FISTULA DOGS
por: Hawkins, W. B., et al.
Publicado: (1936)

Prothrombin complex concentrate (Beriplex P/N) in severe bleeding: experience in a large tertiary hospital
por: Bruce, David, et al.
Publicado: (2008)

Prothrombin Complex Concentrate for Warfarin-Associated Intracranial Bleeding in Neurosurgical Patients: A Single-Center Experience
por: Mačiukaitienė, Jomantė, et al.
Publicado: (2018)

Clinical outcome of patients with a vitamin K antagonist‐associated bleeding treated with prothrombin complex concentrate
por: Brekelmans, Marjolein P. A., et al.
Publicado: (2017)

PROTHROMBIN COMPLEX CONCENTRATE  IN EMERGENCY DEPARTMENT
por: Nesek Adam, Višnja, et al.
Publicado: (2022)

3-Factor versus 4-Factor Prothrombin Complex Concentrates for the Reversal of Vitamin K Antagonist-Associated Coagulopathy: A Systematic Review and Meta-analysis
por: Puchstein, Dorothea, et al.
Publicado: (2023)

Critical appraisal and concerns regarding a meta-analysis on prothrombin complex concentrate (PCC) for trauma-induced coagulopathy: unveiling methodological nuances and treatment variances
por: Antônio, Bruno Caldeira, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_uu1ogikr516cmsj7ds983030ct