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Prothrombin, alone or in complex concentrates or plasma, reduces bleeding in a mouse model of blood exchange-induced coagulopathy

Prothrombin complex concentrates (PCC) are fractionated plasma protein drugs that reverse warfarin anticoagulation. PCC may control more general bleeding. We sought to identify the dominant procoagulant factor in PCC in vivo. We tested PCC or coagulation factor (F) treatment in CD1 mice made coagulo...

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Detalles Bibliográficos
Autores principales:	Eltringham-Smith, Louise J., Yu, Ruoying, Qadri, Syed M., Wang, Yiming, Bhakta, Varsha, Pryzdial, Edward L., Crosby, Jeffrey R., Ni, Heyu, Sheffield, William P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736877/ https://www.ncbi.nlm.nih.gov/pubmed/31506556 http://dx.doi.org/10.1038/s41598-019-49552-9

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