The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines

1,3,5-triazine is an important heterocyclic skeleton for mono, two or three 2-chloroethylamine groups. The study presented here provides novel information on cellular effects of 1,3,5-triazine with mono, two or three 2-chloroethylamine groups in glioblastoma LBC3, LN-18 and LN-229 cell lines. In our...

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Autores principales: Krętowski, Rafał, Drozdowska, Danuta, Kolesińska, Beata, Kamiński, Zbigniew, Frączyk, Justyna, Cechowska-Pasko, Marzanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736897/
https://www.ncbi.nlm.nih.gov/pubmed/30645699
http://dx.doi.org/10.1007/s10637-018-0712-8
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author Krętowski, Rafał
Drozdowska, Danuta
Kolesińska, Beata
Kamiński, Zbigniew
Frączyk, Justyna
Cechowska-Pasko, Marzanna
author_facet Krętowski, Rafał
Drozdowska, Danuta
Kolesińska, Beata
Kamiński, Zbigniew
Frączyk, Justyna
Cechowska-Pasko, Marzanna
author_sort Krętowski, Rafał
collection PubMed
description 1,3,5-triazine is an important heterocyclic skeleton for mono, two or three 2-chloroethylamine groups. The study presented here provides novel information on cellular effects of 1,3,5-triazine with mono, two or three 2-chloroethylamine groups in glioblastoma LBC3, LN-18 and LN-229 cell lines. In our study, the most cytotoxic effect was observed in 1,3,5-triazine with three 2-chloroethylamine groups (12f compound). It has been demonstrated that 12f induce time- and dose-dependent cytotoxicity in all investigated glioma cell lines. Apart from that in glioblastoma cells, treated with 12f compound, we noticed strong induction of apoptosis. In conclusion, this research provides novel information concerning cellular effects of apoptosis in LBC3, LN-18 and LN-229 cell lines. Moreover, we suggest that 12f compound may be a candidate for further evaluation as an effective chemotherapeutic agent for human glioblastoma cells.
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spelling pubmed-67368972019-09-23 The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines Krętowski, Rafał Drozdowska, Danuta Kolesińska, Beata Kamiński, Zbigniew Frączyk, Justyna Cechowska-Pasko, Marzanna Invest New Drugs Preclinical Studies 1,3,5-triazine is an important heterocyclic skeleton for mono, two or three 2-chloroethylamine groups. The study presented here provides novel information on cellular effects of 1,3,5-triazine with mono, two or three 2-chloroethylamine groups in glioblastoma LBC3, LN-18 and LN-229 cell lines. In our study, the most cytotoxic effect was observed in 1,3,5-triazine with three 2-chloroethylamine groups (12f compound). It has been demonstrated that 12f induce time- and dose-dependent cytotoxicity in all investigated glioma cell lines. Apart from that in glioblastoma cells, treated with 12f compound, we noticed strong induction of apoptosis. In conclusion, this research provides novel information concerning cellular effects of apoptosis in LBC3, LN-18 and LN-229 cell lines. Moreover, we suggest that 12f compound may be a candidate for further evaluation as an effective chemotherapeutic agent for human glioblastoma cells. Springer US 2019-01-15 2019 /pmc/articles/PMC6736897/ /pubmed/30645699 http://dx.doi.org/10.1007/s10637-018-0712-8 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Preclinical Studies
Krętowski, Rafał
Drozdowska, Danuta
Kolesińska, Beata
Kamiński, Zbigniew
Frączyk, Justyna
Cechowska-Pasko, Marzanna
The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines
title The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines
title_full The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines
title_fullStr The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines
title_full_unstemmed The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines
title_short The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines
title_sort cellular effects of novel triazine nitrogen mustards in glioblastoma lbc3, ln-18 and ln-229 cell lines
topic Preclinical Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736897/
https://www.ncbi.nlm.nih.gov/pubmed/30645699
http://dx.doi.org/10.1007/s10637-018-0712-8
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