Cargando…

Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice

Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by progressive muscle wasting and weakness and premature death. Glucocorticoids (e.g. prednisolone) remain the only drugs with a favorable impact on DMD patients, but not without side effects. We have demonstrated that gl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ham, Daniel J., Gardner, Anastasia, Kennedy, Tahnee L., Trieu, Jennifer, Naim, Timur, Chee, Annabel, Alves, Francesca M., Caldow, Marissa K., Lynch, Gordon S., Koopman, René
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736947/ https://www.ncbi.nlm.nih.gov/pubmed/31506484 http://dx.doi.org/10.1038/s41598-019-49140-x

Ejemplares similares

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity
por: Hardee, Justin P., et al.
Publicado: (2020)

Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury
por: Swiderski, Kristy, et al.
Publicado: (2019)

Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle
por: Kennedy, Tahnee L., et al.
Publicado: (2017)

Dysfunctional Muscle and Liver Glycogen Metabolism in mdx Dystrophic Mice
por: Stapleton, David I., et al.
Publicado: (2014)

Glycine Protects Muscle Cells From Wasting in vitro via mTORC1 Signaling
por: Caldow, Marissa K., et al.
Publicado: (2019)

Tranilast administration reduces fibrosis and improves fatigue resistance in muscles of mdx dystrophic mice
por: Swiderski, Kristy, et al.
Publicado: (2014)

Functional Substitution by TAT-Utrophin in Dystrophin-Deficient Mice
por: Sonnemann, Kevin J., et al.
Publicado: (2009)

Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis
por: Chen, Hung-Chih, et al.
Publicado: (2017)

Investigating the Potential for Sulforaphane to Attenuate Gastrointestinal Dysfunction in mdx Dystrophic Mice
por: Swiderski, Kristy, et al.
Publicado: (2021)

Altered sodium channel function in dystrophin/utrophin-deficient cardiomyocytes
por: Koenig, Xaver, et al.
Publicado: (2010)

The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophy
por: Guiraud, Simon, et al.
Publicado: (2019)

Sarcospan reduces dystrophic pathology: stabilization of the utrophin–glycoprotein complex
por: Peter, Angela K., et al.
Publicado: (2008)

The Crystal Structures of Dystrophin and Utrophin Spectrin Repeats: Implications for Domain Boundaries
por: Muthu, Muralidharan, et al.
Publicado: (2012)

Marginal Level Dystrophin Expression Improves Clinical Outcome in a Strain of Dystrophin/Utrophin Double Knockout Mice
por: Li, Dejia, et al.
Publicado: (2010)

Phosphorylation alters the mechanical stiffness of a model fragment of the dystrophin homologue utrophin
por: Ramirez, Maria Paz, et al.
Publicado: (2022)

L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism
por: Ham, Daniel J., et al.
Publicado: (2015)

Dystrophic Changes in Extraocular Muscles after Gamma Irradiation in mdx:utrophin(+/−) Mice
por: McDonald, Abby A., et al.
Publicado: (2014)

Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction
por: Mishra, Manoj K., et al.
Publicado: (2017)

Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy
por: Alves, Francesca M., et al.
Publicado: (2022)

Dystrophins, Utrophins, and Associated Scaffolding Complexes: Role in Mammalian Brain and Implications for Therapeutic Strategies
por: Perronnet, Caroline, et al.
Publicado: (2010)

Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia
por: Murphy, Kate T., et al.
Publicado: (2012)

Muscle-specific deletion of SOCS3 increases the early inflammatory response but does not affect regeneration after myotoxic injury
por: Swiderski, Kristy, et al.
Publicado: (2016)

Non-uniform dystrophin re-expression after CRISPR-mediated exon excision in the dystrophin/utrophin double-knockout mouse model of DMD
por: Hanson, Britt, et al.
Publicado: (2022)

Erratum of “Dystrophins, Utrophins, and Associated Scaffolding Complexes: Role in Mammalian Brain and Implications for Therapeutic Strategies”
por: Perronnet, Caroline, et al.
Publicado: (2010)

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation
por: Swiderski, Kristy, et al.
Publicado: (2020)

Metabolic Dysfunction and Altered Mitochondrial Dynamics in the Utrophin-Dystrophin Deficient Mouse Model of Duchenne Muscular Dystrophy
por: Pant, Meghna, et al.
Publicado: (2015)

Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice
por: Boulanger Piette, Antoine, et al.
Publicado: (2018)

Alternative utrophin mRNAs contribute to phenotypic differences between dystrophin‐deficient mice and Duchenne muscular dystrophy
por: Perkins, Kelly J., et al.
Publicado: (2018)

Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles
por: Péladeau, Christine, et al.
Publicado: (2020)

Dystrophin myonuclear domain restoration governs treatment efficacy in dystrophic muscle
por: Morin, Adrien, et al.
Publicado: (2023)

Sildenafil ameliorates cardiomyopathy in dystrophin-null (mdx) mice
por: Parchen, Candace M, et al.
Publicado: (2009)

Autophagy is Impaired in the Tibialis Anterior of Dystrophin Null Mice
por: Spitali, Pietro, et al.
Publicado: (2013)

Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies
por: Janghra, Narinder, et al.
Publicado: (2016)

Chronic Dosing with Membrane Sealant Poloxamer 188 NF Improves Respiratory Dysfunction in Dystrophic Mdx and Mdx/Utrophin(-/-) Mice
por: Markham, Bruce E., et al.
Publicado: (2015)

Novel Adeno-Associated Viral Vector Delivering the Utrophin Gene Regulator Jazz Counteracts Dystrophic Pathology in mdx Mice
por: Strimpakos, Georgios, et al.
Publicado: (2014)

Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice
por: Nogami, Ken'ichiro, et al.
Publicado: (2021)

Transgene expression and differentiation of baculovirus-transduced adipose-derived stem cells from dystrophin-utrophin double knock-out mouse☆
por: Li, Qiuling, et al.
Publicado: (2012)

Daily Treatment with SMTC1100, a Novel Small Molecule Utrophin Upregulator, Dramatically Reduces the Dystrophic Symptoms in the mdx Mouse
por: Tinsley, Jonathon M., et al.
Publicado: (2011)

Sticky utrophin messages
por: Wells, William A.
Publicado: (2001)

Electroporation Enhanced Effect of Dystrophin Splice Switching PNA Oligomers in Normal and Dystrophic Muscle
por: Brolin, Camilla, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_navpb0vf8cvuq88qb2d7po7hsk