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Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression

It is well established that mast cell accumulation accompanies most malignancies. However, the knowledge of how mast cells functionally impact on tumors is still rudimentary. Here we addressed this issue and show that mast cells have anti-proliferative activity on melanoma cells and that this effect...

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Detalles Bibliográficos
Autores principales: Rabelo Melo, Fabio, Santosh Martin, Sebastin, Sommerhoff, Christian P., Pejler, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736983/
https://www.ncbi.nlm.nih.gov/pubmed/31506436
http://dx.doi.org/10.1038/s41419-019-1879-4