Cargando…
Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression
It is well established that mast cell accumulation accompanies most malignancies. However, the knowledge of how mast cells functionally impact on tumors is still rudimentary. Here we addressed this issue and show that mast cells have anti-proliferative activity on melanoma cells and that this effect...
Autores principales: | Rabelo Melo, Fabio, Santosh Martin, Sebastin, Sommerhoff, Christian P., Pejler, Gunnar |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736983/ https://www.ncbi.nlm.nih.gov/pubmed/31506436 http://dx.doi.org/10.1038/s41419-019-1879-4 |
Ejemplares similares
-
The Absence of Tryptase Mcpt6 Causes Elevated Cellular Stress in Response to Modulation of the Histone Acetylation Status in Mast Cells
por: Santosh Martin, Sebastin, et al.
Publicado: (2019) -
Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA
por: Alanazi, Sultan, et al.
Publicado: (2020) -
Mast Cell Tryptase Potentiates Neutrophil Extracellular Trap Formation
por: Pejler, Gunnar, et al.
Publicado: (2021) -
Protective role of mouse mast cell tryptase Mcpt6 in melanoma
por: Grujic, Mirjana, et al.
Publicado: (2020) -
Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells
por: Alanazi, Sultan, et al.
Publicado: (2021)