Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity

The transcription factor Bach2 is a susceptible gene for numerous autoimmune diseases including systemic lupus erythematosus (SLE). Bach2(−/−) mice can develop a lupus-like autoimmune disease. However, the exact cellular and molecular mechanisms via which Bach2 protects the hosts from developing aut...

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Detalles Bibliográficos
Autores principales: Zhang, Heng, Hu, Qianwen, Zhang, Min, Yang, Fang, Peng, Cheng, Zhang, Zhen, Huang, Chuanxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737000/
https://www.ncbi.nlm.nih.gov/pubmed/31552021
http://dx.doi.org/10.3389/fimmu.2019.02050

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