Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer

Penile cancer is normally discovered in an early stage due to its visibility to the patient. This case report demonstrates a morbidly obese patient with a locally advanced penile cancer hidden by fatty tissue. Biopsy showed P16-positive tumor cells, which responded to concurrent chemo-radiotherapy w...

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Detalles Bibliográficos
Autores principales: Nguyen, Cam, Leslie, Stephen, Gross, John, Dietz, Nicholas, Lele, Subodh M., Sirineni, Gopi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737329/
https://www.ncbi.nlm.nih.gov/pubmed/31516836
http://dx.doi.org/10.1016/j.eucr.2019.101009
Descripción
Sumario:Penile cancer is normally discovered in an early stage due to its visibility to the patient. This case report demonstrates a morbidly obese patient with a locally advanced penile cancer hidden by fatty tissue. Biopsy showed P16-positive tumor cells, which responded to concurrent chemo-radiotherapy with no evidence of disease at 24 months of follow-up. We also review the significance of p16-positive cell biology.

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