Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer

Penile cancer is normally discovered in an early stage due to its visibility to the patient. This case report demonstrates a morbidly obese patient with a locally advanced penile cancer hidden by fatty tissue. Biopsy showed P16-positive tumor cells, which responded to concurrent chemo-radiotherapy w...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Cam, Leslie, Stephen, Gross, John, Dietz, Nicholas, Lele, Subodh M., Sirineni, Gopi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737329/
https://www.ncbi.nlm.nih.gov/pubmed/31516836
http://dx.doi.org/10.1016/j.eucr.2019.101009
_version_ 1783450649049956352
author Nguyen, Cam
Leslie, Stephen
Gross, John
Dietz, Nicholas
Lele, Subodh M.
Sirineni, Gopi
author_facet Nguyen, Cam
Leslie, Stephen
Gross, John
Dietz, Nicholas
Lele, Subodh M.
Sirineni, Gopi
author_sort Nguyen, Cam
collection PubMed
description Penile cancer is normally discovered in an early stage due to its visibility to the patient. This case report demonstrates a morbidly obese patient with a locally advanced penile cancer hidden by fatty tissue. Biopsy showed P16-positive tumor cells, which responded to concurrent chemo-radiotherapy with no evidence of disease at 24 months of follow-up. We also review the significance of p16-positive cell biology.
format Online
Article
Text
id pubmed-6737329
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-67373292019-09-12 Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer Nguyen, Cam Leslie, Stephen Gross, John Dietz, Nicholas Lele, Subodh M. Sirineni, Gopi Urol Case Rep Oncology Penile cancer is normally discovered in an early stage due to its visibility to the patient. This case report demonstrates a morbidly obese patient with a locally advanced penile cancer hidden by fatty tissue. Biopsy showed P16-positive tumor cells, which responded to concurrent chemo-radiotherapy with no evidence of disease at 24 months of follow-up. We also review the significance of p16-positive cell biology. Elsevier 2019-09-04 /pmc/articles/PMC6737329/ /pubmed/31516836 http://dx.doi.org/10.1016/j.eucr.2019.101009 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Nguyen, Cam
Leslie, Stephen
Gross, John
Dietz, Nicholas
Lele, Subodh M.
Sirineni, Gopi
Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer
title Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer
title_full Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer
title_fullStr Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer
title_full_unstemmed Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer
title_short Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer
title_sort penile cancer with positive nodes: a case of hpv p16-positivity and its significance, implication of data from head and neck cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737329/
https://www.ncbi.nlm.nih.gov/pubmed/31516836
http://dx.doi.org/10.1016/j.eucr.2019.101009
work_keys_str_mv AT nguyencam penilecancerwithpositivenodesacaseofhpvp16positivityanditssignificanceimplicationofdatafromheadandneckcancer
AT lesliestephen penilecancerwithpositivenodesacaseofhpvp16positivityanditssignificanceimplicationofdatafromheadandneckcancer
AT grossjohn penilecancerwithpositivenodesacaseofhpvp16positivityanditssignificanceimplicationofdatafromheadandneckcancer
AT dietznicholas penilecancerwithpositivenodesacaseofhpvp16positivityanditssignificanceimplicationofdatafromheadandneckcancer
AT lelesubodhm penilecancerwithpositivenodesacaseofhpvp16positivityanditssignificanceimplicationofdatafromheadandneckcancer
AT sirinenigopi penilecancerwithpositivenodesacaseofhpvp16positivityanditssignificanceimplicationofdatafromheadandneckcancer

Ejemplares similares