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Combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: A case report

INTRODUCTION: Immune thrombocytopenic purpura is an acquired thrombocytopenia. Preoperative management of thrombocytopenia is important in patients with gastric cancer. Partial splenic embolization can be effective for patients with thrombocytopenia, but could lead to ischemic necrosis of the remnan...

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Autores principales: Kaneko, Yuki, Saito, Shin, Takahashi, Daijiro, Ui, Takashi, Haruta, Hidenori, Kurashina, Kentaro, Yamaguchi, Hironori, Hosoya, Yoshinori, Kitayama, Joji, Lefor, Alan Kawarai, Sata, Naohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737330/
https://www.ncbi.nlm.nih.gov/pubmed/31505450
http://dx.doi.org/10.1016/j.ijscr.2019.08.027
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author Kaneko, Yuki
Saito, Shin
Takahashi, Daijiro
Ui, Takashi
Haruta, Hidenori
Kurashina, Kentaro
Yamaguchi, Hironori
Hosoya, Yoshinori
Kitayama, Joji
Lefor, Alan Kawarai
Sata, Naohiro
author_facet Kaneko, Yuki
Saito, Shin
Takahashi, Daijiro
Ui, Takashi
Haruta, Hidenori
Kurashina, Kentaro
Yamaguchi, Hironori
Hosoya, Yoshinori
Kitayama, Joji
Lefor, Alan Kawarai
Sata, Naohiro
author_sort Kaneko, Yuki
collection PubMed
description INTRODUCTION: Immune thrombocytopenic purpura is an acquired thrombocytopenia. Preoperative management of thrombocytopenia is important in patients with gastric cancer. Partial splenic embolization can be effective for patients with thrombocytopenia, but could lead to ischemic necrosis of the remnant stomach when performing subtotal gastrectomy with splenectomy. PRESENTATION OF CASE: The patient is an 84-year old woman evaluated for anemia. Endoscopy revealed an advanced gastric cancer with bleeding. The patient also had immune thrombocytopenic purpura with a platelet count <50,000/μL. Administration of platelets did not increase the platelet count. Partial splenic embolization was performed followed by administration of high-dose immunoglobulin. The platelet count was over 50,000/μL preoperatively. The patient underwent combined subtotal gastrectomy and splenectomy, followed by an uneventful course. DISCUSSION: Patients with immune thrombocytopenic purpura and advanced gastric cancer can have anemia. Partial splenic embolization has been used to treat patients with refractory immune thrombocytopenic purpura as an alternative to splenectomy. Preoperative partial splenic embolization and high-dose immunoglobulin therapy resulted an increased platelet count in this patient. Elderly patients with gastric cancer have a high risk of postoperative complications. Patients with gastric cancer undergoing total gastrectomy have an impaired postoperative quality of life compared to those who undergo subtotal gastrectomy. We performed a subtotal gastrectomy and splenectomy as a function-preserving operation, completed safely by maintaining blood flow to the remnant stomach. CONCLUSION: Partial splenic embolization is effective for patients with immune thrombocytopenic purpura and gastric cancer. Combined subtotal gastrectomy and splenectomy is achieved by preserving blood flow to the remnant stomach.
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spelling pubmed-67373302019-09-12 Combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: A case report Kaneko, Yuki Saito, Shin Takahashi, Daijiro Ui, Takashi Haruta, Hidenori Kurashina, Kentaro Yamaguchi, Hironori Hosoya, Yoshinori Kitayama, Joji Lefor, Alan Kawarai Sata, Naohiro Int J Surg Case Rep Article INTRODUCTION: Immune thrombocytopenic purpura is an acquired thrombocytopenia. Preoperative management of thrombocytopenia is important in patients with gastric cancer. Partial splenic embolization can be effective for patients with thrombocytopenia, but could lead to ischemic necrosis of the remnant stomach when performing subtotal gastrectomy with splenectomy. PRESENTATION OF CASE: The patient is an 84-year old woman evaluated for anemia. Endoscopy revealed an advanced gastric cancer with bleeding. The patient also had immune thrombocytopenic purpura with a platelet count <50,000/μL. Administration of platelets did not increase the platelet count. Partial splenic embolization was performed followed by administration of high-dose immunoglobulin. The platelet count was over 50,000/μL preoperatively. The patient underwent combined subtotal gastrectomy and splenectomy, followed by an uneventful course. DISCUSSION: Patients with immune thrombocytopenic purpura and advanced gastric cancer can have anemia. Partial splenic embolization has been used to treat patients with refractory immune thrombocytopenic purpura as an alternative to splenectomy. Preoperative partial splenic embolization and high-dose immunoglobulin therapy resulted an increased platelet count in this patient. Elderly patients with gastric cancer have a high risk of postoperative complications. Patients with gastric cancer undergoing total gastrectomy have an impaired postoperative quality of life compared to those who undergo subtotal gastrectomy. We performed a subtotal gastrectomy and splenectomy as a function-preserving operation, completed safely by maintaining blood flow to the remnant stomach. CONCLUSION: Partial splenic embolization is effective for patients with immune thrombocytopenic purpura and gastric cancer. Combined subtotal gastrectomy and splenectomy is achieved by preserving blood flow to the remnant stomach. Elsevier 2019-08-31 /pmc/articles/PMC6737330/ /pubmed/31505450 http://dx.doi.org/10.1016/j.ijscr.2019.08.027 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kaneko, Yuki
Saito, Shin
Takahashi, Daijiro
Ui, Takashi
Haruta, Hidenori
Kurashina, Kentaro
Yamaguchi, Hironori
Hosoya, Yoshinori
Kitayama, Joji
Lefor, Alan Kawarai
Sata, Naohiro
Combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: A case report
title Combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: A case report
title_full Combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: A case report
title_fullStr Combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: A case report
title_full_unstemmed Combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: A case report
title_short Combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: A case report
title_sort combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: a case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737330/
https://www.ncbi.nlm.nih.gov/pubmed/31505450
http://dx.doi.org/10.1016/j.ijscr.2019.08.027
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