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The Relationship between Corpus Callosum Morphometric Measurements and Age/Gender Characteristics: A Comprehensive MR Imaging Study

OBJECTIVE: The objective of the study was to examine a possible relationship between morphometric corpus callosum (CC) measurements, age, and gender characteristics using MR images. MATERIALS AND METHODS: The medical data and MR examinations of 436 consecutive subjects were retrospectively reviewed....

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Autores principales: Arda, Kemal Niyazi, Akay, Sinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737445/
https://www.ncbi.nlm.nih.gov/pubmed/31538031
http://dx.doi.org/10.25259/JCIS-13-2019
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author Arda, Kemal Niyazi
Akay, Sinan
author_facet Arda, Kemal Niyazi
Akay, Sinan
author_sort Arda, Kemal Niyazi
collection PubMed
description OBJECTIVE: The objective of the study was to examine a possible relationship between morphometric corpus callosum (CC) measurements, age, and gender characteristics using MR images. MATERIALS AND METHODS: The medical data and MR examinations of 436 consecutive subjects were retrospectively reviewed. The CC thickness from five different sites, and additionally splenium length, height, and total length of the CC, and the splenium index (SI) were measured with a mid-sagittal T1-weighted sequence. Those measurements were compared with age and gender characteristics. RESULTS: A weak but statistically significant negative correlation was found between age and thicknesses of genu and all body portions of CC (P = ≤0.001 for all, r = -0.32 for genu, r = -0.317 for B1, r = -0.328 for B2, r = -0.328 for B2, and r = -0.194 for B3 and B4). There was a weak but statistically significant positive correlation between age and the lengths of CC and splenium (P ≤ 0.022 for both, r = 0.112 for CC length and r = 0.11 for splenium length). The second part of the body (B2) was thicker in females (P = 0.014). On the other hand, the CC and splenium lengths were greater in males compared to females (P = 0.029 for both). CONCLUSION: We designed a comprehensive MRI study to investigate a possible relationship between normal morphometric CC measurements in 436 healthy subjects. We preferred splenium length and SI as the main splenium measurements instead of direct splenium thickness, due to discrepancies regarding splenium measurement methods in the medical literature. There was a wide spectrum of results, and we compared those results with existing medical literature.
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spelling pubmed-67374452019-09-19 The Relationship between Corpus Callosum Morphometric Measurements and Age/Gender Characteristics: A Comprehensive MR Imaging Study Arda, Kemal Niyazi Akay, Sinan J Clin Imaging Sci Research Article OBJECTIVE: The objective of the study was to examine a possible relationship between morphometric corpus callosum (CC) measurements, age, and gender characteristics using MR images. MATERIALS AND METHODS: The medical data and MR examinations of 436 consecutive subjects were retrospectively reviewed. The CC thickness from five different sites, and additionally splenium length, height, and total length of the CC, and the splenium index (SI) were measured with a mid-sagittal T1-weighted sequence. Those measurements were compared with age and gender characteristics. RESULTS: A weak but statistically significant negative correlation was found between age and thicknesses of genu and all body portions of CC (P = ≤0.001 for all, r = -0.32 for genu, r = -0.317 for B1, r = -0.328 for B2, r = -0.328 for B2, and r = -0.194 for B3 and B4). There was a weak but statistically significant positive correlation between age and the lengths of CC and splenium (P ≤ 0.022 for both, r = 0.112 for CC length and r = 0.11 for splenium length). The second part of the body (B2) was thicker in females (P = 0.014). On the other hand, the CC and splenium lengths were greater in males compared to females (P = 0.029 for both). CONCLUSION: We designed a comprehensive MRI study to investigate a possible relationship between normal morphometric CC measurements in 436 healthy subjects. We preferred splenium length and SI as the main splenium measurements instead of direct splenium thickness, due to discrepancies regarding splenium measurement methods in the medical literature. There was a wide spectrum of results, and we compared those results with existing medical literature. Scientific Scholar 2019-06-28 /pmc/articles/PMC6737445/ /pubmed/31538031 http://dx.doi.org/10.25259/JCIS-13-2019 Text en © 2019 - Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science https://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Arda, Kemal Niyazi
Akay, Sinan
The Relationship between Corpus Callosum Morphometric Measurements and Age/Gender Characteristics: A Comprehensive MR Imaging Study
title The Relationship between Corpus Callosum Morphometric Measurements and Age/Gender Characteristics: A Comprehensive MR Imaging Study
title_full The Relationship between Corpus Callosum Morphometric Measurements and Age/Gender Characteristics: A Comprehensive MR Imaging Study
title_fullStr The Relationship between Corpus Callosum Morphometric Measurements and Age/Gender Characteristics: A Comprehensive MR Imaging Study
title_full_unstemmed The Relationship between Corpus Callosum Morphometric Measurements and Age/Gender Characteristics: A Comprehensive MR Imaging Study
title_short The Relationship between Corpus Callosum Morphometric Measurements and Age/Gender Characteristics: A Comprehensive MR Imaging Study
title_sort relationship between corpus callosum morphometric measurements and age/gender characteristics: a comprehensive mr imaging study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737445/
https://www.ncbi.nlm.nih.gov/pubmed/31538031
http://dx.doi.org/10.25259/JCIS-13-2019
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