Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice

OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting. METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Change...

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Autores principales: Fokin, Andrej, Minderis, Petras, Venckunas, Tomas, Lionikas, Arimantas, Kvedaras, Mindaugas, Ratkevicius, Aivaras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society of Musculoskeletal and Neuronal Interactions 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737554/
https://www.ncbi.nlm.nih.gov/pubmed/31475942
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author Fokin, Andrej
Minderis, Petras
Venckunas, Tomas
Lionikas, Arimantas
Kvedaras, Mindaugas
Ratkevicius, Aivaras
author_facet Fokin, Andrej
Minderis, Petras
Venckunas, Tomas
Lionikas, Arimantas
Kvedaras, Mindaugas
Ratkevicius, Aivaras
author_sort Fokin, Andrej
collection PubMed
description OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting. METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied. RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline. CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting.
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spelling pubmed-67375542019-09-16 Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice Fokin, Andrej Minderis, Petras Venckunas, Tomas Lionikas, Arimantas Kvedaras, Mindaugas Ratkevicius, Aivaras J Musculoskelet Neuronal Interact Original Article OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting. METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied. RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline. CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting. International Society of Musculoskeletal and Neuronal Interactions 2019 /pmc/articles/PMC6737554/ /pubmed/31475942 Text en Copyright: © Journal of Musculoskeletal and Neuronal Interactions http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Fokin, Andrej
Minderis, Petras
Venckunas, Tomas
Lionikas, Arimantas
Kvedaras, Mindaugas
Ratkevicius, Aivaras
Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice
title Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice
title_full Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice
title_fullStr Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice
title_full_unstemmed Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice
title_short Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice
title_sort myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737554/
https://www.ncbi.nlm.nih.gov/pubmed/31475942
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