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Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke

BACKGROUND: Ischemic stroke (IS) is a serious cardiovascular disease and is associated with several single nucleotide polymorphisms (SNPs). However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in IS remains unknown. Our study aimed to explore whether CYP4F2 polymorphisms...

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Autores principales: Wu, Yuan, Zhao, Junjie, Zhao, Yonglin, Huang, Tingqin, Ma, Xudong, Pang, Honggang, Zhang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737589/
https://www.ncbi.nlm.nih.gov/pubmed/31510945
http://dx.doi.org/10.1186/s12881-019-0888-6
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author Wu, Yuan
Zhao, Junjie
Zhao, Yonglin
Huang, Tingqin
Ma, Xudong
Pang, Honggang
Zhang, Ming
author_facet Wu, Yuan
Zhao, Junjie
Zhao, Yonglin
Huang, Tingqin
Ma, Xudong
Pang, Honggang
Zhang, Ming
author_sort Wu, Yuan
collection PubMed
description BACKGROUND: Ischemic stroke (IS) is a serious cardiovascular disease and is associated with several single nucleotide polymorphisms (SNPs). However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in IS remains unknown. Our study aimed to explore whether CYP4F2 polymorphisms influenced IS risk in the Han Chinese population. METHODS: We selected 477 patients and 495 controls to do a case-control study, and five SNPs in CYP4F2 gene were successfully genotyped. And we evaluated the associations using the Chi-squared test, independent sample t test, and genetic models analyses. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: In this study, rs12459936 and rs3093144 were associated with IS risk in the overall. After stratified analysis by age (> 61 years), rs3093193 and rs3093144 were related to an increased risk of IS, whereas rs12459936 was related to a decreased risk of IS. In addition, we found that three SNPs (rs3093193, rs3093144 and rs12459936) were associated with the susceptibility to IS in males. We also found five SNPs in the CYP4F2 gene had strong linkage. CONCLUSIONS: Three SNPs (rs3093193, rs3093144 and rs12459936) in the CYP4F2 were associated with IS risk in a Chinese Han population. And, CYP4F2 gene may be involved in the development of IS. SUPPLEMENTARY INFORMATION: Supplementary information accompanies this paper at (10.1186/s12881-019-0888-6).
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spelling pubmed-67375892019-09-16 Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke Wu, Yuan Zhao, Junjie Zhao, Yonglin Huang, Tingqin Ma, Xudong Pang, Honggang Zhang, Ming BMC Med Genet Research Article BACKGROUND: Ischemic stroke (IS) is a serious cardiovascular disease and is associated with several single nucleotide polymorphisms (SNPs). However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in IS remains unknown. Our study aimed to explore whether CYP4F2 polymorphisms influenced IS risk in the Han Chinese population. METHODS: We selected 477 patients and 495 controls to do a case-control study, and five SNPs in CYP4F2 gene were successfully genotyped. And we evaluated the associations using the Chi-squared test, independent sample t test, and genetic models analyses. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: In this study, rs12459936 and rs3093144 were associated with IS risk in the overall. After stratified analysis by age (> 61 years), rs3093193 and rs3093144 were related to an increased risk of IS, whereas rs12459936 was related to a decreased risk of IS. In addition, we found that three SNPs (rs3093193, rs3093144 and rs12459936) were associated with the susceptibility to IS in males. We also found five SNPs in the CYP4F2 gene had strong linkage. CONCLUSIONS: Three SNPs (rs3093193, rs3093144 and rs12459936) in the CYP4F2 were associated with IS risk in a Chinese Han population. And, CYP4F2 gene may be involved in the development of IS. SUPPLEMENTARY INFORMATION: Supplementary information accompanies this paper at (10.1186/s12881-019-0888-6). BioMed Central 2019-09-11 /pmc/articles/PMC6737589/ /pubmed/31510945 http://dx.doi.org/10.1186/s12881-019-0888-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wu, Yuan
Zhao, Junjie
Zhao, Yonglin
Huang, Tingqin
Ma, Xudong
Pang, Honggang
Zhang, Ming
Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
title Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
title_full Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
title_fullStr Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
title_full_unstemmed Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
title_short Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
title_sort genetic variants in cyp4f2 were significantly correlated with susceptibility to ischemic stroke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737589/
https://www.ncbi.nlm.nih.gov/pubmed/31510945
http://dx.doi.org/10.1186/s12881-019-0888-6
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