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Identifying asymptomatic Leishmania infections in non-endemic villages in Gedaref state, Sudan

OBJECTIVES: Infection with the causative agent of visceral leishmaniasis (VL) may be either symptomatic or asymptomatic. In this study we aimed at investigating the prevalence of asymptomatic infections of leishmania in non-endemic villages in Gedaref state, Sudan. A descriptive cross-sectional stud...

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Autores principales: Mohamed, Nouh Saad, Osman, Hussam A., Muneer, Mohamed S., Samy, Abdallah M., Ahmed, Ayman, Mohammed, Anwar O., Siddig, Emmanuel Edwar, Abdel Hamid, Muzamil M., Ali, Mohamed Siralkhatim, Omer, Rihab A., Elaagip, Arwa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737656/
https://www.ncbi.nlm.nih.gov/pubmed/31511056
http://dx.doi.org/10.1186/s13104-019-4608-2
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author Mohamed, Nouh Saad
Osman, Hussam A.
Muneer, Mohamed S.
Samy, Abdallah M.
Ahmed, Ayman
Mohammed, Anwar O.
Siddig, Emmanuel Edwar
Abdel Hamid, Muzamil M.
Ali, Mohamed Siralkhatim
Omer, Rihab A.
Elaagip, Arwa H.
author_facet Mohamed, Nouh Saad
Osman, Hussam A.
Muneer, Mohamed S.
Samy, Abdallah M.
Ahmed, Ayman
Mohammed, Anwar O.
Siddig, Emmanuel Edwar
Abdel Hamid, Muzamil M.
Ali, Mohamed Siralkhatim
Omer, Rihab A.
Elaagip, Arwa H.
author_sort Mohamed, Nouh Saad
collection PubMed
description OBJECTIVES: Infection with the causative agent of visceral leishmaniasis (VL) may be either symptomatic or asymptomatic. In this study we aimed at investigating the prevalence of asymptomatic infections of leishmania in non-endemic villages in Gedaref state, Sudan. A descriptive cross-sectional study conducted during September and October 2014. Blood samples were collected for serological and molecular analysis. Sticky-traps, knockdown spray and CDC-miniature light traps were used for the collection of sandflies. RESULTS: Ninety-Five participants were included; 52 from Abukishma, 15 Algadamblia Tirfa, 25 Abualnaja and 3 were from Algadamblia Aljabal. Females constituted 56 (58.9%) of the study participants while males were 39 (41.1%). The most frequent age group was > 40-years (54.7%). Balanites/Acacia trees were the most planted tree inside the houses; 78 (82.1%). Also, 85 (89.5%) of the participants breed animals inside the house. DAT test revealed 5 positive participants (5.2%). 4/5 DAT positive were past VL infection. PCR detected 35 (36.8%) positive participants. A total of 31/35 was considered asymptomatic infections based on PCR. Households planted Balanites/Acacia trees or breed domestic animals were found in high percentages with L. donovani PCR positive participants (60.1%, 91.4%). No statistically significant was found for VL associated risk factors and VL asymptomatic participants.
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spelling pubmed-67376562019-09-16 Identifying asymptomatic Leishmania infections in non-endemic villages in Gedaref state, Sudan Mohamed, Nouh Saad Osman, Hussam A. Muneer, Mohamed S. Samy, Abdallah M. Ahmed, Ayman Mohammed, Anwar O. Siddig, Emmanuel Edwar Abdel Hamid, Muzamil M. Ali, Mohamed Siralkhatim Omer, Rihab A. Elaagip, Arwa H. BMC Res Notes Research Note OBJECTIVES: Infection with the causative agent of visceral leishmaniasis (VL) may be either symptomatic or asymptomatic. In this study we aimed at investigating the prevalence of asymptomatic infections of leishmania in non-endemic villages in Gedaref state, Sudan. A descriptive cross-sectional study conducted during September and October 2014. Blood samples were collected for serological and molecular analysis. Sticky-traps, knockdown spray and CDC-miniature light traps were used for the collection of sandflies. RESULTS: Ninety-Five participants were included; 52 from Abukishma, 15 Algadamblia Tirfa, 25 Abualnaja and 3 were from Algadamblia Aljabal. Females constituted 56 (58.9%) of the study participants while males were 39 (41.1%). The most frequent age group was > 40-years (54.7%). Balanites/Acacia trees were the most planted tree inside the houses; 78 (82.1%). Also, 85 (89.5%) of the participants breed animals inside the house. DAT test revealed 5 positive participants (5.2%). 4/5 DAT positive were past VL infection. PCR detected 35 (36.8%) positive participants. A total of 31/35 was considered asymptomatic infections based on PCR. Households planted Balanites/Acacia trees or breed domestic animals were found in high percentages with L. donovani PCR positive participants (60.1%, 91.4%). No statistically significant was found for VL associated risk factors and VL asymptomatic participants. BioMed Central 2019-09-11 /pmc/articles/PMC6737656/ /pubmed/31511056 http://dx.doi.org/10.1186/s13104-019-4608-2 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Mohamed, Nouh Saad
Osman, Hussam A.
Muneer, Mohamed S.
Samy, Abdallah M.
Ahmed, Ayman
Mohammed, Anwar O.
Siddig, Emmanuel Edwar
Abdel Hamid, Muzamil M.
Ali, Mohamed Siralkhatim
Omer, Rihab A.
Elaagip, Arwa H.
Identifying asymptomatic Leishmania infections in non-endemic villages in Gedaref state, Sudan
title Identifying asymptomatic Leishmania infections in non-endemic villages in Gedaref state, Sudan
title_full Identifying asymptomatic Leishmania infections in non-endemic villages in Gedaref state, Sudan
title_fullStr Identifying asymptomatic Leishmania infections in non-endemic villages in Gedaref state, Sudan
title_full_unstemmed Identifying asymptomatic Leishmania infections in non-endemic villages in Gedaref state, Sudan
title_short Identifying asymptomatic Leishmania infections in non-endemic villages in Gedaref state, Sudan
title_sort identifying asymptomatic leishmania infections in non-endemic villages in gedaref state, sudan
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737656/
https://www.ncbi.nlm.nih.gov/pubmed/31511056
http://dx.doi.org/10.1186/s13104-019-4608-2
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