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Chemical Enhancement of Irreversible Electroporation: A Review and Future Suggestions

Irreversible electroporation has raised great interest in the past decade as a means of destroying cancers in a way that does not involve heat. Irreversible electroporation is a novel ablation technology that uses short high-voltage electrical pulses to enhance the permeability of tumor cell membran...

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Autores principales: Chen, Ying, Moser, Michael A. J., Luo, Yigang, Zhang, Wenjun, Zhang, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737874/
https://www.ncbi.nlm.nih.gov/pubmed/31500518
http://dx.doi.org/10.1177/1533033819874128
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author Chen, Ying
Moser, Michael A. J.
Luo, Yigang
Zhang, Wenjun
Zhang, Bing
author_facet Chen, Ying
Moser, Michael A. J.
Luo, Yigang
Zhang, Wenjun
Zhang, Bing
author_sort Chen, Ying
collection PubMed
description Irreversible electroporation has raised great interest in the past decade as a means of destroying cancers in a way that does not involve heat. Irreversible electroporation is a novel ablation technology that uses short high-voltage electrical pulses to enhance the permeability of tumor cell membranes and generate irreversible nano-sized structural defects or pores, thus leading to cell death. Irreversible electroporation has many advantages over thermal therapies due to its nonthermal mechanism: (1) reduced risk of injury to surrounding organs and (2) no “heat-sink” effect due to nearby blood vessels. However, so far, it has been difficult for irreversible electroporation to completely ablate large tumors (eg, >3 cm in diameter). In order to overcome this problem, many preclinical and clinical studies have been performed to improve the efficacy of IRE in the treatment of large size of tumors through a chemical perspective. Due to the distribution of electric field, irreversible electroporation region, reversible electroporation region, and intact region can be found in the treatment of irreversible electroporation. Thus, 2 types of chemical enhancements of irreversible electroporation were discussed in the article, such as the reversible electroporation region enhanced and the irreversible electroporation region enhanced. Specifically, the state-of-the-art results regarding the following approaches that have the potential to be used in the enhancement of irreversible electroporation were systematically reviewed in the article, including (1) combination with cytotoxic drugs, (2) calcium electroporation, (3) modification of cell membrane, and (4) modification of the tumor cell microenvironment. In the end, we concluded with 4 issues that should be addressed in the future for improving irreversible electroporation further in a chemical way.
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spelling pubmed-67378742019-09-18 Chemical Enhancement of Irreversible Electroporation: A Review and Future Suggestions Chen, Ying Moser, Michael A. J. Luo, Yigang Zhang, Wenjun Zhang, Bing Technol Cancer Res Treat Review Irreversible electroporation has raised great interest in the past decade as a means of destroying cancers in a way that does not involve heat. Irreversible electroporation is a novel ablation technology that uses short high-voltage electrical pulses to enhance the permeability of tumor cell membranes and generate irreversible nano-sized structural defects or pores, thus leading to cell death. Irreversible electroporation has many advantages over thermal therapies due to its nonthermal mechanism: (1) reduced risk of injury to surrounding organs and (2) no “heat-sink” effect due to nearby blood vessels. However, so far, it has been difficult for irreversible electroporation to completely ablate large tumors (eg, >3 cm in diameter). In order to overcome this problem, many preclinical and clinical studies have been performed to improve the efficacy of IRE in the treatment of large size of tumors through a chemical perspective. Due to the distribution of electric field, irreversible electroporation region, reversible electroporation region, and intact region can be found in the treatment of irreversible electroporation. Thus, 2 types of chemical enhancements of irreversible electroporation were discussed in the article, such as the reversible electroporation region enhanced and the irreversible electroporation region enhanced. Specifically, the state-of-the-art results regarding the following approaches that have the potential to be used in the enhancement of irreversible electroporation were systematically reviewed in the article, including (1) combination with cytotoxic drugs, (2) calcium electroporation, (3) modification of cell membrane, and (4) modification of the tumor cell microenvironment. In the end, we concluded with 4 issues that should be addressed in the future for improving irreversible electroporation further in a chemical way. SAGE Publications 2019-09-09 /pmc/articles/PMC6737874/ /pubmed/31500518 http://dx.doi.org/10.1177/1533033819874128 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Chen, Ying
Moser, Michael A. J.
Luo, Yigang
Zhang, Wenjun
Zhang, Bing
Chemical Enhancement of Irreversible Electroporation: A Review and Future Suggestions
title Chemical Enhancement of Irreversible Electroporation: A Review and Future Suggestions
title_full Chemical Enhancement of Irreversible Electroporation: A Review and Future Suggestions
title_fullStr Chemical Enhancement of Irreversible Electroporation: A Review and Future Suggestions
title_full_unstemmed Chemical Enhancement of Irreversible Electroporation: A Review and Future Suggestions
title_short Chemical Enhancement of Irreversible Electroporation: A Review and Future Suggestions
title_sort chemical enhancement of irreversible electroporation: a review and future suggestions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737874/
https://www.ncbi.nlm.nih.gov/pubmed/31500518
http://dx.doi.org/10.1177/1533033819874128
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