Cargando…
Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria
The Gram-negative bacterial envelope is an essential interface between the intracellular and harsh extracellular environment. Envelope stress responses (ESRs) are crucial to the maintenance of this barrier and function to detect and respond to perturbations in the envelope, caused by environmental s...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737893/ https://www.ncbi.nlm.nih.gov/pubmed/31552196 http://dx.doi.org/10.3389/fcimb.2019.00313 |
_version_ | 1783450742666821632 |
---|---|
author | Hews, Claire L. Cho, Timothy Rowley, Gary Raivio, Tracy L. |
author_facet | Hews, Claire L. Cho, Timothy Rowley, Gary Raivio, Tracy L. |
author_sort | Hews, Claire L. |
collection | PubMed |
description | The Gram-negative bacterial envelope is an essential interface between the intracellular and harsh extracellular environment. Envelope stress responses (ESRs) are crucial to the maintenance of this barrier and function to detect and respond to perturbations in the envelope, caused by environmental stresses. Pathogenic bacteria are exposed to an array of challenging and stressful conditions during their lifecycle and, in particular, during infection of a host. As such, maintenance of envelope homeostasis is essential to their ability to successfully cause infection. This review will discuss our current understanding of the σ(E)- and Cpx-regulated ESRs, with a specific focus on their role in the virulence of a number of model pathogens. |
format | Online Article Text |
id | pubmed-6737893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67378932019-09-24 Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria Hews, Claire L. Cho, Timothy Rowley, Gary Raivio, Tracy L. Front Cell Infect Microbiol Cellular and Infection Microbiology The Gram-negative bacterial envelope is an essential interface between the intracellular and harsh extracellular environment. Envelope stress responses (ESRs) are crucial to the maintenance of this barrier and function to detect and respond to perturbations in the envelope, caused by environmental stresses. Pathogenic bacteria are exposed to an array of challenging and stressful conditions during their lifecycle and, in particular, during infection of a host. As such, maintenance of envelope homeostasis is essential to their ability to successfully cause infection. This review will discuss our current understanding of the σ(E)- and Cpx-regulated ESRs, with a specific focus on their role in the virulence of a number of model pathogens. Frontiers Media S.A. 2019-09-04 /pmc/articles/PMC6737893/ /pubmed/31552196 http://dx.doi.org/10.3389/fcimb.2019.00313 Text en Copyright © 2019 Hews, Cho, Rowley and Raivio. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Hews, Claire L. Cho, Timothy Rowley, Gary Raivio, Tracy L. Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria |
title | Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria |
title_full | Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria |
title_fullStr | Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria |
title_full_unstemmed | Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria |
title_short | Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria |
title_sort | maintaining integrity under stress: envelope stress response regulation of pathogenesis in gram-negative bacteria |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737893/ https://www.ncbi.nlm.nih.gov/pubmed/31552196 http://dx.doi.org/10.3389/fcimb.2019.00313 |
work_keys_str_mv | AT hewsclairel maintainingintegrityunderstressenvelopestressresponseregulationofpathogenesisingramnegativebacteria AT chotimothy maintainingintegrityunderstressenvelopestressresponseregulationofpathogenesisingramnegativebacteria AT rowleygary maintainingintegrityunderstressenvelopestressresponseregulationofpathogenesisingramnegativebacteria AT raiviotracyl maintainingintegrityunderstressenvelopestressresponseregulationofpathogenesisingramnegativebacteria |