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Dissection of GTPase-activating proteins reveals functional asymmetry in the COPI coat of budding yeast

The Arf GTPase controls formation of the COPI vesicle coat. Recent structural models of COPI revealed the positioning of two Arf1 molecules in contrasting molecular environments. Each of these pockets for Arf1 is expected to also accommodate an Arf GTPase-activating protein (ArfGAP). Structural evid...

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Detalles Bibliográficos
Autores principales: Arakel, Eric C., Huranova, Martina, Estrada, Alejandro F., Rau, E-Ming, Spang, Anne, Schwappach, Blanche
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737914/
https://www.ncbi.nlm.nih.gov/pubmed/31331965
http://dx.doi.org/10.1242/jcs.232124