Cargando…

Unique trophoblast chromatin environment mediated by the PcG protein SFMBT2

Stem/progenitor cells are maintained by a chromatin environment, mediated in part by Polycomb group (PcG) proteins, which depress differentiation. The trophoblast-specific PcG protein SFMBT2 is known to be required for maintenance of trophoblast progenitors. Rather than binding to trophoblast-specif...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Priscilla, Miri, Kamelia, Varmuza, Susannah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737984/
https://www.ncbi.nlm.nih.gov/pubmed/31391163
http://dx.doi.org/10.1242/bio.043638
_version_ 1783450756864540672
author Tang, Priscilla
Miri, Kamelia
Varmuza, Susannah
author_facet Tang, Priscilla
Miri, Kamelia
Varmuza, Susannah
author_sort Tang, Priscilla
collection PubMed
description Stem/progenitor cells are maintained by a chromatin environment, mediated in part by Polycomb group (PcG) proteins, which depress differentiation. The trophoblast-specific PcG protein SFMBT2 is known to be required for maintenance of trophoblast progenitors. Rather than binding to trophoblast-specific genes repressed in TSC, SFMBT2 is concentrated at chromocentres and regions rich in repetitive elements, specifically LINE sequences and major satellites, suggesting that it is involved in higher-order organization of the trophoblast genome. It is also found enriched at a subset of ncRNAs. Comparison of ChIP-seq datasets for other chromatin proteins reveals several stereotypical distribution patterns, suggesting that SFMBT2 interacts with several different types of chromatin complexes specific to the trophoblast lineage.
format Online
Article
Text
id pubmed-6737984
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher The Company of Biologists Ltd
record_format MEDLINE/PubMed
spelling pubmed-67379842019-09-12 Unique trophoblast chromatin environment mediated by the PcG protein SFMBT2 Tang, Priscilla Miri, Kamelia Varmuza, Susannah Biol Open Research Article Stem/progenitor cells are maintained by a chromatin environment, mediated in part by Polycomb group (PcG) proteins, which depress differentiation. The trophoblast-specific PcG protein SFMBT2 is known to be required for maintenance of trophoblast progenitors. Rather than binding to trophoblast-specific genes repressed in TSC, SFMBT2 is concentrated at chromocentres and regions rich in repetitive elements, specifically LINE sequences and major satellites, suggesting that it is involved in higher-order organization of the trophoblast genome. It is also found enriched at a subset of ncRNAs. Comparison of ChIP-seq datasets for other chromatin proteins reveals several stereotypical distribution patterns, suggesting that SFMBT2 interacts with several different types of chromatin complexes specific to the trophoblast lineage. The Company of Biologists Ltd 2019-08-07 /pmc/articles/PMC6737984/ /pubmed/31391163 http://dx.doi.org/10.1242/bio.043638 Text en © 2019. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/4.0This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article
Tang, Priscilla
Miri, Kamelia
Varmuza, Susannah
Unique trophoblast chromatin environment mediated by the PcG protein SFMBT2
title Unique trophoblast chromatin environment mediated by the PcG protein SFMBT2
title_full Unique trophoblast chromatin environment mediated by the PcG protein SFMBT2
title_fullStr Unique trophoblast chromatin environment mediated by the PcG protein SFMBT2
title_full_unstemmed Unique trophoblast chromatin environment mediated by the PcG protein SFMBT2
title_short Unique trophoblast chromatin environment mediated by the PcG protein SFMBT2
title_sort unique trophoblast chromatin environment mediated by the pcg protein sfmbt2
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737984/
https://www.ncbi.nlm.nih.gov/pubmed/31391163
http://dx.doi.org/10.1242/bio.043638
work_keys_str_mv AT tangpriscilla uniquetrophoblastchromatinenvironmentmediatedbythepcgproteinsfmbt2
AT mirikamelia uniquetrophoblastchromatinenvironmentmediatedbythepcgproteinsfmbt2
AT varmuzasusannah uniquetrophoblastchromatinenvironmentmediatedbythepcgproteinsfmbt2