A novel NPM1-RARG-NPM1 chimeric fusion in acute myeloid leukaemia resembling acute promyelocytic leukaemia but resistant to all-trans retinoic acid and arsenic trioxide

The RARG gene is a member of the nuclear hormone receptor superfamily and shares high homology with RARA and RARB. RARA is involved in translocation with PML in acute promyelocytic leukaemia (APL). Little is known about RARB or RARG rearrangement. RARG fusions were reported in only five APL patients...

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Detalles Bibliográficos
Autores principales: Chen, Xue, Wang, Fang, Zhang, Yang, Teng, Wen, Cao, Panxiang, Ma, Xiaoli, Liu, Mingyue, Tian, Yaoyao, Wang, Tong, Nie, Daijing, Zhang, Jing, Liu, Hongxing, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738072/
https://www.ncbi.nlm.nih.gov/pubmed/30996344
http://dx.doi.org/10.1038/s41416-019-0456-z

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