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Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression

BACKGROUND: Crenolanib is a tyrosine kinase inhibitor targeting PDGFR-α, PDGFR-β and Fms related tyrosine kinase-3 (FLT3) that is currently evaluated in several clinical trials. Although platelet-derived growth factor receptor (PDGFR) signalling pathway is believed to play an important role in angio...

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Detalles Bibliográficos
Autores principales:	Berndsen, Robert H., Castrogiovanni, Cédric, Weiss, Andrea, Rausch, Magdalena, Dallinga, Marchien G., Miljkovic-Licina, Marijana, Klaassen, Ingeborg, Meraldi, Patrick, van Beijnum, Judy R., Nowak-Sliwinska, Patrycja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738084/ https://www.ncbi.nlm.nih.gov/pubmed/31235865 http://dx.doi.org/10.1038/s41416-019-0498-2

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