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High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer

BACKGROUND: Microsatellite-unstable (MSI) tumours show a high load of mutational neoantigens, as a consequence of DNA mismatch repair deficiency. Consequently, MSI tumours commonly present with dense immune infiltration and develop immune evasion mechanisms. Whether improved lymphocyte recruitment c...

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Detalles Bibliográficos
Autores principales:	Pfuderer, Pauline L., Ballhausen, Alexej, Seidler, Florian, Stark, Hans-Jürgen, Grabe, Niels, Frayling, Ian M., Ager, Ann, von Knebel Doeberitz, Magnus, Kloor, Matthias, Ahadova, Aysel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738093/ https://www.ncbi.nlm.nih.gov/pubmed/31358939 http://dx.doi.org/10.1038/s41416-019-0514-6

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